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HIPK4 is a homeodomain-interacting protein kinase and has been demonstrated to phosphorylate p53. HIPK4 encodes a member of the homeodomain interacting protein kinase (HIPK) family of proteins. While other members of this family are found throughout vertebrates, this member is present only in mammals. Compared to other members of this family, the encoded protein lacks a nuclear localization signal and a C-terminal autoinhibitory domain. The encoded protein exhibits kinase activity and may phosphorylate the tumor suppressor protein p53.
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Protein Aliases: Homeodomain-interacting protein kinase 4; testicular tissue protein Li 87
Gene Aliases: Gm162; HIPK4
UniProt ID: (Human) Q8NE63, (Rat) Q4V793, (Mouse) Q3V016
Entrez Gene ID: (Human) 147746, (Rat) 308449, (Mouse) 233020
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