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Proteintech
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Immunogen sequence: TAKKVEGNK GTKSLKESEQ ESEEEILAQK KEQREEEVEE EEKEEDEEKG DWKPRTRSNG RRKSAREERS CKQKSQAKRL LGDSDSEEEQ KEAASSGDDS GRDREPPVQR KSEDRTQLKG GKRLSGSSED EEDSGKGEPT AKGSRKMARL GSTSGEESDL EREVSDSEAG GGPQGERKNR SSKKSSRKGR TRSSSSSSDG SPEAKGGKAG SGRRGEDHPA VMRLKRYIRA CGAHRNYKKL LGSCCSHKER LSILRAELEA LGMKGTPSLG KCRALKEQRE EAAEVASLDV ANIISGSGRP RRRTAWNPLG EAAPPGELYR RTLDSDEERP RPAPPDWSHM RGIISSDGES N (207-556 aa encoded by BC000588)
The HIRA protein shares sequence similarity with Hir1p and Hir2p, the two corepressors of histone gene transcription characterized in the yeast, Saccharomyces cerevisiae. The structural features of the HIRA protein suggest that it may function as part of a multiprotein complex. Several cDNAs encoding HIRA-interacting proteins, or HIRIPs, have been identified. In vitro, the protein encoded by this gene binds HIRA, as well as H2B and H3 core histones, indicating that a complex containing HIRA-HIRIP3 could function in some aspects of chromatin and histone metabolism. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: HIRA-interacting protein 3; hirip3
Gene Aliases: B130036O03; C86302; HIRIP3
UniProt ID: (Human) Q9BW71, (Mouse) Q8BLH7
Entrez Gene ID: (Human) 8479, (Mouse) 233876
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