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Positive test controls include: HL-60, HeLa, U-937, Jurkat, Mouse skeletal muscle, Mouse liver, Rat skeletal muscle. The target is usually found in the following locations: Nucleus.
Immunogen sequence: GRRGEDHPAV MRLKRYIRAC GAHRNYKKLL GSCCSHKERL SILRAELEAL GMKGTPSLGK CRALKEQREE AAEVASLDVA NIISGSGRPR RRTAWNPLGE AAPPGELYRR TLDSDEERPR PAPPDWSHMR GIISSDGESN
The HIRA protein shares sequence similarity with Hir1p and Hir2p, the two corepressors of histone gene transcription characterized in the yeast, Saccharomyces cerevisiae. The structural features of the HIRA protein suggest that it may function as part of a multiprotein complex. Several cDNAs encoding HIRA-interacting proteins, or HIRIPs, have been identified. In vitro, the protein encoded by this gene binds HIRA, as well as H2B and H3 core histones, indicating that a complex containing HIRA-HIRIP3 could function in some aspects of chromatin and histone metabolism. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: HIRA-interacting protein 3; hirip3
Gene Aliases: B130036O03; C86302; HIRIP3
UniProt ID: (Human) Q9BW71, (Mouse) Q8BLH7
Entrez Gene ID: (Human) 8479, (Mouse) 233876, (Rat) 361650
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