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Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: H2B histone family, member T; H2B K; HIRA-interacting protein 1; histone 1, H2bk; histone family member; Histone H2B type 1-K
Gene Aliases: H2B/S; H2BC12; H2BFAiii; H2BFT; H2BK; HIRIP1; HIST1H2BK
UniProt ID: (Human) O60814
Entrez Gene ID: (Human) 85236
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