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Abnova
HLA-DMA Polyclonal Antibody, MaxPab™
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FIGURE: 1 / 5
HLA-DMA Antibody (H00003108-D01P) in WB
Western Blot analysis of HLA-DMA expression in transfected 293T cell line (H00003108-T01) by HLA-DMA MaxPab polyclonal antibody.
Lane 1: HLA-DMA transfected lysate(29.20 KDa).
Lane 2: Non-transfected lysate.
Lane 1: HLA-DMA transfected lysate(29.20 KDa).
Lane 2: Non-transfected lysate.
Product Details
H00003108-D01P
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
HLA-DMA (NP_006111.2, 1 a.a. approximately 261 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
See Label
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: MGHEQNQGAA LLQMLPLLWL LPHSWAVPEA PTPMWPDDLQ NHTFLHTVYC QDGSPSVGLS EAYDEDQLFF FDFSQNTRVP RLPEFADWAQ EQGDAPAILF DKEFCEWMIQ QIGPKLDGKI PVSRGFPIAE VFTLKPLEFG KPNTLVCFVS NLFPPMLTVN WQHHSVPVEG FGPTFVSAVD GLSFQAFSYL NFTPEPSDIF SCIVTHEIDR YTAIAYWVPR NALPSDLLEN VLCGVAFGLG VLGIIVGIVL IIYFRKPCSG D
Target Information
HLA-DMA belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta chain (DMB), both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail.
HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: class II histocompatibility antigen, M alpha chain; DAAP-27A1.5; HLA class II histocompatibility antigen, DM alpha chain; MHC class II antigen DMA; Really interesting new gene 6 protein
Gene Aliases: D6S222E; DMA; HLA-DMA; HLADM; RING6
UniProt ID: (Human) P28067
Entrez Gene ID: (Human) 3108
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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