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NeoBiotechnologies
HLA-DRB (MHC II) Monoclonal Antibody (Bra30)
Product Details
3123-MSM4-P1ABX
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Dog,
Chimpanzee,
Human,
Non-human primate,
Rodent
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
Bra30
Immunogen
Human REH cells (non-T, non-B leukemia cell line)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A/G
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Target Information
HLA-DR beta refers to the beta chain of the HLA-DR protein complex, which is a member of the human leukocyte antigen (HLA) class II molecule. The HLA-DR beta chain is encoded by the HLA-DRB gene. HLA-DR beta is primarily on the surface of antigen-presenting cells, including dendritic cells, macrophages, and B cells. These cells play a crucial role in the immune system by capturing, processing, and presenting antigens to T cells for immune recognition. HLA-DR beta is a critical component of the immune system, facilitating the recognition and response to extracellular antigens. Its function in presenting antigenic peptides to CD4+ T cells plays a vital role in the activation of adaptive immune responses. HLA-DR beta consists of an extracellular domain, a transmembrane domain, and a cytoplasmic tail. The extracellular domain contains the peptide-binding groove, which interacts with antigenic peptides. The transmembrane domain anchors the HLA-DR beta chain to the cell membrane, while the cytoplasmic tail is involved in intracellular signaling events.
HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DAMC-146E17.2; DLA class II histocompatibility antigen, DR-1 beta chain; DLA DRBB1 beta chain; DLA-DR beta; DR beta-5; DR-9; DR2-beta-2; DR7; DR9; DRB1 transplantation antigen; Dw2; DW2.2/DR2.2; HLA class II histocompatibility antigen, DR beta 3 chain; HLA class II histocompatibility antigen, DR beta 4 chain; HLA class II histocompatibility antigen, DR beta 5 chain; HLA class II histocompatibility antigen, DR-1 beta chain; HLA class II histocompatibility antigen, DR-5 beta chain; HLA class II histocompatibility antigen, DRB1 beta chain; HLA class II histocompatibility antigen, DRB1-7 beta chain; HLA class II histocompatibility antigen, DRB1-9 beta chain; HLA-DRB1; HLA-DRB5; human leucocyte antigen DRB1; human leucocyte antigen DRB3; human leucocyte antigen DRB4; human leucocyte antigen DRB5; Human leukocyte antigen DRB1; leukocyte antigen; leukocyte antigen class II; lymphocyte antigen DRB1; MHC class I antigen; MHC Class II antigen; MHC class II antigen beta chain; MHC class II antigen DR beta 3 chain; MHC class II antigen DRB1*9; MHC class II antigen DRB3; MHC class II antigen DRB4; MHC class II antigen DRB5; MHC class II antigen HLA-DR-beta; MHC class II DLA-DR-beta-1; MHC class II DLA-DRB; MHC class II DR beta 1; MHC class II HLA beta chain; MHC class II HLA-DR beta 1 chain; MHC class II HLA-DR beta 3 chain; MHC class II HLA-DR-beta cell surface glycoprotein; MHC class II HLA-DRw10-beta; MHC class2 antigen; MHC HLA DR-beta chain; MHC HLA-DR-beta cell surface glycoprotein; MHC HLA-DR-beta chain
Gene Aliases: DLA-DRB1; DLA-DRBB1; DR-4; DR4; DRB; DRB1; DRB4; DRBB1; DRw10; HLA-DR1B; HLA-DR3B; HLA-DR4B; HLA-DRB; HLA-DRB1; HLA-DRB3; HLA-DRB4; HLA-DRB5; LA-DRB; SS1
UniProt ID: (Dog) P18470, (Human) P01911, (Human) P01913, (Human) P13762, (Human) Q30154
Entrez Gene ID: (Dog) 474860, (Human) 3123, (Human) 3125, (Human) 3126, (Human) 3127
antigen processing and presentation of exogenous peptide antigen via MHC class II
T cell costimulation
T cell receptor signaling pathway
interferon-gamma-mediated signaling pathway
antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
immune response
signal transduction
polysaccharide assembly with MHC class II protein complex
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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