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Invitrogen
HMBOX1 Polyclonal Antibody
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HMBOX1 Antibody (PA5-21558) in ICC/IF
Immunocytochemistry-Immunofluorescence analysis of HMBOX1 was performed in HeLa cells fixed in 4% paraformaldehyde at RT for 15 min. Green: HMBOX1 Polyclonal Antibody (Product # PA5-21558) diluted at 1:500. Red: alpha Tubulin, a cytoskeleton marker. Blue: Hoechst 33342 staining.
Product Details
PA5-21558
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human HMBOX1. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 10% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_11154826
Product Specific Information
Recommended positive controls: HeLa, HepG2, Molt-4, Raji.
Predicted reactivity: Mouse (99%), Xenopus laevis (96%), Chicken (98%), Bovine (100%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
HMBOX1 is located at the boundary of 8p12.3 and 8p21.1. HMBOX1 proteins are highly conserved in human, mouse, rat, chicken and Xenopus laevis. Functional HMBOX1::EGFP (enhanced green fluorescent protein) fusion protein revealed that HMBOX1 accumulated more in cytoplasm than in nucleus. HMBOX1 is a transcription repressor. Human HMBOX1 is widely expressed in 18 tissues, and it is highly expressed in pancreas. Hmbox1 is widely expressed in mouse pancreas and the expression of this gene can also be detected in pallium, hippocampus and hypothalamus.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Homeobox telomere-binding protein 1; Homeobox-containing protein 1; homeobox-containing protein PBHNF; Telomere-associated homeobox-containing protein 1
Gene Aliases: HMBOX1; HNF1LA; HOT1; PBHNF; TAH1
UniProt ID: (Human) Q6NT76
Entrez Gene ID: (Human) 79618
RNA-dependent DNA biosynthetic process
transcription, DNA-templated
positive regulation of telomere maintenance via telomerase
positive regulation of chromatin binding
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of telomerase activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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