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Invitrogen
HMGA2 Polyclonal Antibody
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HMGA2 Antibody (PA5-25276) in WB
Western blot was performed using Anti-HMGA2 Polyclonal Antibody (Product # PA5-25276) and a 18 kDa band corresponding to High mobility group protein HMGI-C was observed. Nuclear enriched extracts (30 µg lysate) of HCT 116 (Lane 1), SW480 (Lane 2), HT-29 (Lane 3), Hep G2 (Lane 4), ACHN (Lane 5), Caki-1 (Lane 6), A549 (Lane 7), A549 treated with 10 ng/mL TGF-B1 for 48 hrs (Lane 8) and NIH/3T3 (Lane 9) were electrophoresed using NuPAGE™ 12% Bis-Tris Protein Gel (Product # NP0342BOX). Resolved proteins were then transferred onto a Nitrocellulo... View More
Product Details
PA5-25276
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 64-92 amino acids from the C-terminal region of human HMGA2
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A, Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2542776
Product Specific Information
This antibody is predicted to react with mouse based on sequence homology.
Target Information
HMGA2, previously known as HMGI-C, belongs to the group of high mobility chromosomal proteins that have the AT-hook DNA-binding motif. It is highly and ubiquitously expressed during embryogenesis. Chromosomal rearrangements of the HMGA2 gene and overexpression are frequently associated with benign and malignant tumors, respectively. Human and mouse HMGA2 shares 95% amino acid sequence identity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: High mobility group AT-hook protein 2; High mobility group protein HMGI-C; high-mobility group (nonhistone chromosomal) protein isoform I-C; High-mobility group protein HMGI-C
Gene Aliases: BABL; HMGA2; HMGI-C; HMGIC; LIPO; STQTL9
UniProt ID: (Human) P52926
Entrez Gene ID: (Human) 8091
regulatory region DNA binding
transcription factor activity, transcription factor binding
core promoter binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
AT DNA binding
DNA-(apurinic or apyrimidinic site) lyase activity
DNA-dependent protein kinase activity
protein binding
transcription factor binding
DNA binding, bending
nucleosomal DNA binding
cAMP response element binding
MH2 domain binding
MH1 domain binding
SMAD binding
5'-deoxyribose-5-phosphate lyase activity
C2H2 zinc finger domain binding
negative regulation of transcription from RNA polymerase II promoter
epithelial to mesenchymal transition
chondrocyte differentiation
mesodermal-endodermal cell signaling
base-excision repair
chromatin organization
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
mitotic nuclear division
mitotic G2 DNA damage checkpoint
multicellular organism development
response to virus
regulation of cell cycle process
positive regulation of gene expression
chromosome condensation
chromosome breakage
heterochromatin assembly
histone H2A-S139 phosphorylation
senescence-associated heterochromatin focus assembly
endodermal cell differentiation
chondrocyte proliferation
regulation of growth
DNA damage response, detection of DNA damage
positive regulation of apoptotic process
negative regulation of apoptotic process
negative regulation of DNA binding
negative regulation by host of viral transcription
fat cell differentiation
negative regulation of single stranded viral RNA replication via double stranded DNA intermediate
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
mesodermal cell differentiation
mesenchymal cell differentiation
stem cell differentiation
cell division
positive regulation of cell cycle arrest
oncogene-induced cell senescence
regulation of stem cell population maintenance
positive regulation of stem cell proliferation
positive regulation of transcription regulatory region DNA binding
positive regulation of cellular response to X-ray
positive regulation of cellular senescence
positive regulation of response to DNA damage stimulus
negative regulation of double-strand break repair via nonhomologous end joining
regulation of cellular response to drug
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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