Proteintech

HMGCS1 Polyclonal Antibody

HMGCS1 Antibody in Immunocytochemistry (ICC/IF)

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HMGCS1 Antibody (17643-1-AP) in ICC/IF

Immunofluorescent analysis of HepG2 cells, using HMGCS1 antibody 17643-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IGG (red).

HMGCS1 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

17643-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:4,000

View 22 publications 22 publications

Immunohistochemistry (IHC)

View 3 publications 3 publications

Immunocytochemistry (ICC/IF)

1:10-1:100

View 2 publications 2 publications

Immunoprecipitation (IP)

0.5-4.0 µg

View 1 publication 1 publication

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

HMGCS1 Fusion Protein Ag11825 (171-520 aa encoded by BC083514)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: TGGVGAVAL LIGPNAPLIF ERGLRGTHMQ HAYDFYKPDM LSEYPIVDGK LSIQCYLSAL DRCYSVYCKK IHAQWQKEGN DKDFTLNDFG FMIFHSPYCK LVQKSLARML LNDFLNDQNR DKNSIYSGLE AFGDVKLEDT YFDRDVEKAF MKASSELFSQ KTKASLLVSN QNGNMYTSSV YGSLASVLAQ YSPQQLAGKR IGVFSYGSGL AATLYSLKVT QDATPGSALD KITASLCDLK SRLDSRTGVA PDVFAENMKL REDTYHLVNY IPQGSIDSLF EGTWYLVRVD EKHRRTYARR PTPNDDTLDE GVGLVHSNIA TEHIPSPAKK VPRLPATAAE PEAAVISNGE H (171-520 aa encoded by BC083514)

Target Information

This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

ERRα Up-Regulates Invadopodia Formation by Targeting HMGCS1 to Promote Endometrial Cancer Invasion and Metastasis.

International journal of molecular sciences

Tang S,Ma J,Su P,Lei H,Tong Y,Cai L,Xu S,Mao X,Sun P

Thu Feb 16 00:00:00 UTC 2023

ERRα Up-Regulates Invadopodia Formation by Targeting HMGCS1 to Promote Endometrial Cancer Invasion and Metastasis.

International journal of molecular sciences

Tang S,Ma J,Su P,Lei H,Tong Y,Cai L,Xu S,Mao X,Sun P

Thu Feb 16 00:00:00 UTC 2023

P4HA1 activates HMGCS1 to promote nasopharyngeal carcinoma ferroptosis resistance and progression.

Cellular signalling

Zhou R,Qiu L,Zhou L,Geng R,Yang S,Wu J

Mon May 01 00:00:00 UTC 2023

MiR-122-5p regulates the mevalonate pathway by targeting p53 in non-small cell lung cancer.

Cell death & disease

Zheng YK,Zhou ZS,Wang GZ,Tu JY,Cheng HB,Ma SZ,Ke C,Wang Y,Jian QP,Shu YH,Wu XW

Sat Apr 01 00:00:00 UTC 2023

MiR-122-5p regulates the mevalonate pathway by targeting p53 in non-small cell lung cancer.

Cell death & disease

Zheng YK,Zhou ZS,Wang GZ,Tu JY,Cheng HB,Ma SZ,Ke C,Wang Y,Jian QP,Shu YH,Wu XW

Sat Apr 01 00:00:00 UTC 2023

Targeting the mevalonate pathway suppresses ARID1A-inactivated cancers by promoting pyroptosis.

Cancer cell

Zhou W,Liu H,Yuan Z,Zundell J,Towers M,Lin J,Lombardi S,Nie H,Murphy B,Yang T,Wang C,Liao L,Goldman AR,Kannan T,Kossenkov AV,Drapkin R,Montaner LJ,Claiborne DT,Zhang N,Wu S,Zhang R

Mon Apr 10 00:00:00 UTC 2023

Phyllanthus Niruri L. Exerts Protective Effects Against the Calcium Oxalate-Induced Renal Injury via Ellgic Acid.

Frontiers in pharmacology

Li MT,Liu LL,Zhou Q,Huang LX,Shi YX,Hou JB,Lu HT,Yu B,Chen W,Guo ZY

Mon Jun 26 00:00:00 UTC 2023

Phyllanthus Niruri L. Exerts Protective Effects Against the Calcium Oxalate-Induced Renal Injury via Ellgic Acid.

Frontiers in pharmacology

Li MT,Liu LL,Zhou Q,Huang LX,Shi YX,Hou JB,Lu HT,Yu B,Chen W,Guo ZY

Mon Jun 26 00:00:00 UTC 2023

Phyllanthus Niruri L. Exerts Protective Effects Against the Calcium Oxalate-Induced Renal Injury via Ellgic Acid.

Frontiers in pharmacology

Li MT,Liu LL,Zhou Q,Huang LX,Shi YX,Hou JB,Lu HT,Yu B,Chen W,Guo ZY

Mon Jun 26 00:00:00 UTC 2023

Phyllanthus Niruri L. Exerts Protective Effects Against the Calcium Oxalate-Induced Renal Injury via Ellgic Acid.

Frontiers in pharmacology

Li MT,Liu LL,Zhou Q,Huang LX,Shi YX,Hou JB,Lu HT,Yu B,Chen W,Guo ZY

Mon Jun 26 00:00:00 UTC 2023

Upregulation of Superenhancer-Driven LncRNA FASRL by USF1 Promotes De Novo Fatty Acid Biosynthesis to Exacerbate Hepatocellular Carcinoma.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Peng JY,Cai DK,Zeng RL,Zhang CY,Li GC,Chen SF,Yuan XQ,Peng L

Fri Oct 28 00:00:00 UTC 2022

Itraconazole Inhibits the Growth of Cutaneous Squamous Cell Carcinoma by Targeting HMGCS1/ACSL4 Axis.

Frontiers in pharmacology

Xu C,Zhuo Y,Liu Y,Chen H

Sat Mar 05 00:00:00 UTC 2022

Krüppel-like Factor 13 Promotes HCC Progression by Transcriptional Regulation of HMGCS1-mediated Cholesterol Synthesis.

Journal of clinical and translational hepatology

Chen CC,Xie XM,Zhao XK,Zuo S,Li HY

Wed Dec 28 00:00:00 UTC 2022

Discovery and Application of Postnatal Nucleus Pulposus Progenitors Essential for Intervertebral Disc Homeostasis and Degeneration.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Gao B,Jiang B,Xing W,Xie Z,Luo Z,Zou W

Sun May 01 00:00:00 UTC 2022

TDP-43 mediates SREBF2-regulated gene expression required for oligodendrocyte myelination.

The Journal of cell biology

Ho WY,Chang JC,Lim K,Cazenave-Gassiot A,Nguyen AT,Foo JC,Muralidharan S,Viera-Ortiz A,Ong SJM,Hor JH,Agrawal I,Hoon S,Arogundade OA,Rodriguez MJ,Lim SM,Kim SH,Ravits J,Ng SY,Wenk MR,Lee EB,Tucker-Kellogg G,Ling SC

Mon Sep 06 00:00:00 UTC 2021

TDP-43 mediates SREBF2-regulated gene expression required for oligodendrocyte myelination.

The Journal of cell biology

Mon Sep 06 00:00:00 UTC 2021

TDP-43 mediates SREBF2-regulated gene expression required for oligodendrocyte myelination.

The Journal of cell biology

Mon Sep 06 00:00:00 UTC 2021

TDP-43 mediates SREBF2-regulated gene expression required for oligodendrocyte myelination.

The Journal of cell biology

Mon Sep 06 00:00:00 UTC 2021

Transcriptomic Analysis Reveals the Protective Effects of Empagliflozin on Lipid Metabolism in Nonalcoholic Fatty Liver Disease.

Frontiers in pharmacology

Ma Y,Kan C,Qiu H,Liu Y,Hou N,Han F,Shi J,Sun X

Sat Jan 08 00:00:00 UTC 2022

miRNA-223 Suppresses Mouse Gallstone Formation by Targeting Key Transporters in Hepatobiliary Cholesterol Secretion Pathway.

International journal of biological sciences

Zhao F,Ma S,Zhou Y,Wei B,Hao Z,Cui X,Xing L,Liu G,Jin L,Ma T,Shi L

Mon Dec 20 00:00:00 UTC 2021

Astrocytic ApoE reprograms neuronal cholesterol metabolism and histone-acetylation-mediated memory.

Neuron

Li X,Zhang J,Li D,He C,He K,Xue T,Wan L,Zhang C,Liu Q

Wed Mar 17 00:00:00 UTC 2021

Mild Hypothermia Attenuates Hepatic Ischemia-Reperfusion Injury through Regulating the JAK2/STAT3-CPT1a-Dependent Fatty Acid β-Oxidation.

Oxidative medicine and cellular longevity

Wang W,Hu X,Xia Z,Liu Z,Zhong Z,Lu Z,Liu A,Ye S,Cao Q,Wang Y,Zhu F,Ye Q

Wed Dec 16 00:00:00 UTC 2020

Deletion of OSBPL2 in auditory cells increases cholesterol biosynthesis and drives reactive oxygen species production by inhibiting AMPK activity.

Cell death & disease

Wang H,Lin C,Yao J,Shi H,Zhang C,Wei Q,Lu Y,Chen Z,Xing G,Cao X

Mon Aug 19 00:00:00 UTC 2019

Activation of Mitochondrial Unfolded Protein Response in SHSY5Y Expressing APP Cells and APP/PS1 Mice.

Frontiers in cellular neuroscience

Shen Y,Ding M,Xie Z,Liu X,Yang H,Jin S,Xu S,Zhu Z,Wang Y,Wang D,Xu L,Zhou X,Wang P,Bi J

Wed Sep 30 00:00:00 UTC 2020

OSBPL2 deficiency upregulate SQLE expression increasing intracellular cholesterol and cholesteryl ester by AMPK/SP1 and SREBF2 signalling pathway.

Experimental cell research

Zhang C,Zhang H,Zhang M,Lin C,Wang H,Yao J,Wei Q,Lu Y,Chen Z,Xing G,Cao X

Tue Oct 15 00:00:00 UTC 2019

The Age-dependent Elevation of miR-335-3p Leads to Reduced Cholesterol and Impaired Memory in Brain.

Neuroscience

Raihan O,Brishti A,Molla MR,Li W,Zhang Q,Xu P,Khan MI,Zhang J,Liu Q

Mon Oct 15 00:00:00 UTC 2018

The Age-dependent Elevation of miR-335-3p Leads to Reduced Cholesterol and Impaired Memory in Brain.

Neuroscience

Raihan O,Brishti A,Molla MR,Li W,Zhang Q,Xu P,Khan MI,Zhang J,Liu Q

Mon Oct 15 00:00:00 UTC 2018

Potent effects of dioscin against obesity in mice.

Scientific reports

Liu M,Xu L,Yin L,Qi Y,Xu Y,Han X,Zhao Y,Sun H,Yao J,Lin Y,Liu K,Peng J

Thu Jan 22 00:00:00 UTC 2015

Potent effects of dioscin against obesity in mice.

Scientific reports

Liu M,Xu L,Yin L,Qi Y,Xu Y,Han X,Zhao Y,Sun H,Yao J,Lin Y,Liu K,Peng J

Thu Jan 22 00:00:00 UTC 2015

Total saponins from Rosa laevigata Michx fruit attenuates hepatic steatosis induced by high-fat diet in rats.

Food & function

Dong D,Qi Y,Xu L,Yin L,Xu Y,Han X,Zhao Y,Peng J

Mon Dec 01 00:00:00 UTC 2014

Total saponins from Rosa laevigata Michx fruit attenuates hepatic steatosis induced by high-fat diet in rats.

Food & function

Dong D,Qi Y,Xu L,Yin L,Xu Y,Han X,Zhao Y,Peng J

Mon Dec 01 00:00:00 UTC 2014

Protective effects of dioscin against alcohol-induced liver injury.

Archives of toxicology

Xu T,Zheng L,Xu L,Yin L,Qi Y,Xu Y,Han X,Peng J

Sat Mar 01 00:00:00 UTC 2014

Protective effects of dioscin against alcohol-induced liver injury.

Archives of toxicology

Xu T,Zheng L,Xu L,Yin L,Qi Y,Xu Y,Han X,Peng J

Sat Mar 01 00:00:00 UTC 2014

Protective effects of dioscin against alcohol-induced liver injury.

Archives of toxicology

Xu T,Zheng L,Xu L,Yin L,Qi Y,Xu Y,Han X,Peng J

Sat Mar 01 00:00:00 UTC 2014

The endoplasmic reticulum coat protein II transport machinery coordinates cellular lipid secretion and cholesterol biosynthesis.

The Journal of biological chemistry

Fryer LG,Jones B,Duncan EJ,Hutchison CE,Ozkan T,Williams PA,Alder O,Nieuwdorp M,Townley AK,Mensenkamp AR,Stephens DJ,Dallinga-Thie GM,Shoulders CC

Fri Feb 14 00:00:00 UTC 2014

The endoplasmic reticulum coat protein II transport machinery coordinates cellular lipid secretion and cholesterol biosynthesis.

The Journal of biological chemistry

Fryer LG,Jones B,Duncan EJ,Hutchison CE,Ozkan T,Williams PA,Alder O,Nieuwdorp M,Townley AK,Mensenkamp AR,Stephens DJ,Dallinga-Thie GM,Shoulders CC

Fri Feb 14 00:00:00 UTC 2014

Identification of proteins that mediate the pro-viral functions of the interferon stimulated gene 15 in hepatitis C virus replication.

Antiviral research

Real CI,Megger DA,Sitek B,Jahn-Hofmann K,Ickenstein LM,John MJ,Walker A,Timm J,Kuhlmann K,Eisenacher M,Meyer HE,Gerken G,Broering R,Schlaak JF

Sun Dec 01 00:00:00 UTC 2013

Identification of proteins that mediate the pro-viral functions of the interferon stimulated gene 15 in hepatitis C virus replication.

Antiviral research

Real CI,Megger DA,Sitek B,Jahn-Hofmann K,Ickenstein LM,John MJ,Walker A,Timm J,Kuhlmann K,Eisenacher M,Meyer HE,Gerken G,Broering R,Schlaak JF

Sun Dec 01 00:00:00 UTC 2013

Effects of flavonoids from Rosa laevigata Michx fruit against high-fat diet-induced non-alcoholic fatty liver disease in rats.

Food chemistry

Zhang S,Zheng L,Dong D,Xu L,Yin L,Qi Y,Han X,Lin Y,Liu K,Peng J

Sun Dec 01 00:00:00 UTC 2013

Effects of flavonoids from Rosa laevigata Michx fruit against high-fat diet-induced non-alcoholic fatty liver disease in rats.

Food chemistry

Zhang S,Zheng L,Dong D,Xu L,Yin L,Qi Y,Han X,Lin Y,Liu K,Peng J

Sun Dec 01 00:00:00 UTC 2013

Quantitative proteomics reveals that enzymes of the ketogenic pathway are associated with prostate cancer progression.

Molecular & cellular proteomics : MCP

Saraon P,Cretu D,Musrap N,Karagiannis GS,Batruch I,Drabovich AP,van der Kwast T,Mizokami A,Morrissey C,Jarvi K,Diamandis EP

Sat Jun 01 00:00:00 UTC 2013

Quantitative proteomics reveals that enzymes of the ketogenic pathway are associated with prostate cancer progression.

Molecular & cellular proteomics : MCP

Saraon P,Cretu D,Musrap N,Karagiannis GS,Batruch I,Drabovich AP,van der Kwast T,Mizokami A,Morrissey C,Jarvi K,Diamandis EP

Sat Jun 01 00:00:00 UTC 2013

Bioinformatics

Protein Aliases: 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase; 3-hydroxy-3-methylglutaryl coenzyme A synthase; 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble); 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble); HMG-CoA synthase; hydroxymethylglutaryl-CoA synthase 1; Hydroxymethylglutaryl-CoA synthase, cytoplasmic

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Gene Aliases: B130032C06Rik; HMGCS; HMGCS1

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UniProt ID: (Human) Q01581, (Rat) P17425, (Mouse) Q8JZK9

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Entrez Gene ID: (Human) 3157, (Rat) 29637, (Mouse) 208715

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Function(s)

hydroxymethylglutaryl-CoA synthase activity drug binding isomerase activity protein homodimerization activity organic acid binding catalytic activity transferase activity

Process(es)

liver development cholesterol biosynthetic process brain development isoprenoid biosynthetic process male gonad development response to low light intensity stimulus response to hormone response to organic substance response to organonitrogen compound response to organic cyclic compound response to purine-containing compound response to vitamin E response to gonadotropin response to drug response to tellurium ion response to lipoprotein particle response to cholesterol cellular response to follicle-stimulating hormone stimulus cellular response to cholesterol cellular response to organic cyclic compound lipid metabolic process steroid biosynthetic process metabolic process steroid metabolic process cholesterol metabolic process sterol biosynthetic process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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HMGCS1 Polyclonal Antibody

HMGCS1 Antibody (17643-1-AP) in ICC/IF

Product Details

17643-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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