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Invitrogen
HMGCS2 Polyclonal Antibody
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HMGCS2 Antibody (PA5-85502) in IHC (P)
HMGCS2 Polyclonal Antibody detects HMGCS2 protein at mitochondria on human liver carcinoma by immunohistochemical analysis. Sample: Paraffin-embedded human liver carcinoma. HMGCS2 Polyclonal Antibody (Product # PA5-85502) diluted at 1:500. Antigen Retrieval: EDTA based buffer, pH 8.0, 15 min.
Product Details
PA5-85502
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human HMGCS2. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2792642
Product Specific Information
Keep as concentrated solution.
Predicted reactivity: Mouse (85%), Rat (85%), Bovine (83%).
Positive Control: human HMGCS2-transfected 293T cells.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The protein encoded by this gene belongs to the HMG-CoA synthase family. It is a mitochondrial enzyme that catalyzes the first reaction of ketogenesis, a metabolic pathway that provides lipid-derived energy for various organs during times of carbohydrate deprivation, such as fasting. Mutations in this gene are associated with HMG-CoA synthase deficiency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 3-hydroxy-3-methylglutaryl coenzyme A synthase; 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial); 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial); HMG-CoA synthase; Hydroxymethylglutaryl-CoA synthase, mitochondrial; testicular tissue protein Li 88
Gene Aliases: HMGCS2
UniProt ID: (Human) P54868
Entrez Gene ID: (Human) 3158
kidney development
liver development
cholesterol biosynthetic process
brain development
midgut development
response to nutrient
isoprenoid biosynthetic process
response to temperature stimulus
response to metal ion
lung development
cellular response to insulin stimulus
multicellular organismal response to stress
response to testosterone
response to glucagon
response to triglyceride
response to monosaccharide
response to prostaglandin F
response to drug
response to starvation
response to ethanol
ketone body biosynthetic process
response to cAMP
response to growth hormone
adipose tissue development
response to linoleic acid
cellular response to lipopolysaccharide
cellular response to amino acid stimulus
cellular response to glucocorticoid stimulus
cellular response to fatty acid
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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