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Invitrogen
HMGCS2 Recombinant Rabbit Monoclonal Antibody (JE54-76)
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FIGURE: 1 / 4
HMGCS2 Antibody (MA5-44837) in IHC (P)
Immunohistochemistry analysis of HMGCS2 in paraffin-embedded human kidney tissue. The section was pre-treated using heat mediated antigen retrieval with Tris-EDTA buffer (pH 8.0-8.4) for 20 minutes. The tissues were blocked in 5% BSA for 30 minutes at room temperature, washed with ddH2O and PBS, and then probed with HMGCS2 Monoclonal antibody (Product # MA5-44837) using a dilution of 1:50 for 30 minutes at ... View More
Product Details
MA5-44837
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
JE54-76
Immunogen
Synthetic peptide within human HMGCS2 aa 459-508/508.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2931294
Target Information
The protein encoded by this gene belongs to the HMG-CoA synthase family. It is a mitochondrial enzyme that catalyzes the first reaction of ketogenesis, a metabolic pathway that provides lipid-derived energy for various organs during times of carbohydrate deprivation, such as fasting. Mutations in this gene are associated with HMG-CoA synthase deficiency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 3-hydroxy-3-methylglutary-Coenzyme A synthase 2; 3-hydroxy-3-methylglutaryl coenzyme A synthase; 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial); 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial); HMG-CoA synthase; hydroxymethylglutaryl-CoA synthase 2; Hydroxymethylglutaryl-CoA synthase, mitochondrial; testicular tissue protein Li 88
Gene Aliases: 1300002P16; Hmgcs1; HMGCS2; mHS; Mt3h3mg
UniProt ID: (Human) P54868, (Rat) P22791, (Mouse) P54869
Entrez Gene ID: (Human) 3158, (Rat) 24450, (Mouse) 15360
kidney development
liver development
cholesterol biosynthetic process
brain development
midgut development
response to nutrient
isoprenoid biosynthetic process
response to temperature stimulus
response to bacterium
response to metal ion
response to organic cyclic compound
lung development
response to insulin
cellular response to insulin stimulus
cellular response to hormone stimulus
multicellular organismal response to stress
response to testosterone
response to glucagon
response to triglyceride
response to monosaccharide
response to prostaglandin F
response to drug
response to starvation
response to peptide hormone
response to ethanol
ketone body biosynthetic process
response to glucocorticoid
response to cAMP
response to growth hormone
adipose tissue development
response to fatty acid
response to linoleic acid
cellular response to lipopolysaccharide
cellular response to amino acid stimulus
cellular response to glucocorticoid stimulus
cellular response to fatty acid
cellular response to organic cyclic compound
lipid metabolic process
steroid biosynthetic process
metabolic process
steroid metabolic process
cholesterol metabolic process
sterol biosynthetic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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