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Proteintech
HMHA1 Polyclonal Antibody
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Product Details
14832-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
HMHA1 Fusion Protein Ag6636 (804-1136 aa encoded by BC065223)
Conjugate
Form
Liquid
Concentration
0.33 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: RVEKLCQAF ENGKELVELS QASPHDISNV LKLYLRQLPE PLISFRLYHE LVGLAKDSLK AEAEAKAASR GRQDGSESEA VAVALAGRLR ELLRDLPPEN RASLQYLLRH LRRIVEVEQD NKMTPGNLGI VFGPTLLRPR PTEATVSLSS LVDYPHQARV IETLIVHYGL VFEEEPEETP GGQDESSNQR AEVVVQVPYL EAGEAVVYPL QEAAADGCRE SRVVSNDSDS DLEEASELLS SSEASALGHL SFLEQQQSEA SLEVASGSHS GSEEQLEATA REDGDGDEDG PAQQLSGFNT NQSNNVLQAP LPPMRLRGGR MTLGSCRERQ PEFV (804-1136 aa encoded by BC065223)
Target Information
Contains a GTPase activator for the Rho-type GTPases (RhoGAP) domain that would be able to negatively regulate the actin cytoskeleton as well as cell spreading. However, also contains N-terminally a BAR-domain which is able to play an autoinhibitory effect on this RhoGAP activity. Precursor of the histocompatibility antigen HA-1. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and its expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. Specifically, mismatching for mHag HA-1 which is recognized as immunodominant, is shown to be associated with the development of severe GVHD after HLA-identical BMT. HA-1 is presented to the cell surface by MHC class I HLA-A*0201, but also by other HLA-A alleles. This complex specifically elicits donor-cytotoxic T-lymphocyte (CTL) reactivity against hematologic malignancies after treatment by HLA-identical allogenic BMT. It induces cell recognition and lysis by CTL.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: histocompatibility (minor) HA-1; minor histocompatibility antigen HA-1; Minor histocompatibility protein HA-1; Rho GTPase-activating protein 45
Gene Aliases: 6330406L22Rik; ARHGAP45; AW539505; HA-1; HLA-HA1; HMHA1; KIAA0223; RGD1308662
UniProt ID: (Human) Q92619, (Mouse) Q3TBD2
Entrez Gene ID: (Human) 23526, (Rat) 314618, (Mouse) 70719
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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