Invitrogen

HNF4A/HNF4G Polyclonal Antibody

Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-100879

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human HNF4A(Accession P41235), corresponding to amino acid residues A287-L337.
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2815829

Product Specific Information

Antibody detects endogenous levels of total HNF4 alpha /gamma.

Target Information

The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants encoding several different isoforms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: alpha transcription factor 4; hepatic nuclear factor 4 alpha; hepatic nuclear factor 4, alpha; hepatocyte nuclear factor 4, alpha; hepatocyte nuclear factor 4, gamma; Hepatocyte nuclear factor 4-alpha; Hepatocyte nuclear factor 4-gamma; HNF-4-alpha; HNF-4-gamma; HNF4 alpha; HNF4alpha10; HNF4alpha10/11/12; HNF4alpha11; HNF4alpha12; Nuclear receptor 2A1; Nuclear receptor subfamily 2 group A member 1; Nuclear receptor subfamily 2 group A member 2; TCF-14; Transcription factor 14; Transcription factor HNF-4

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Gene Aliases: FRTS4; HNF-4; HNF4; HNF4A; HNF4a7; HNF4a8; HNF4a9; HNF4alpha; HNF4G; MODY; MODY1; NR2A1; NR2A2; NR2A21; NR2A3; TCF; TCF14

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UniProt ID: (Human) P41235, (Human) Q14541, (Mouse) P49698, (Rat) P22449, (Mouse) Q9WUU6

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Entrez Gene ID: (Human) 3172, (Human) 3174, (Mouse) 15378, (Rat) 25735, (Mouse) 30942, (Rat) 365744

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Function(s)
fatty-acyl-CoA binding RNA polymerase II core promoter sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II activating transcription factor binding DNA binding transcription factor activity, sequence-specific DNA binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding steroid hormone receptor activity RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding receptor binding fatty acid binding protein binding zinc ion binding palmitoyl-CoA hydrolase activity protein homodimerization activity transcription regulatory region DNA binding sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding transcription factor binding metal ion binding repressing transcription factor binding
Process(es)
transcription, DNA-templated regulation of transcription, DNA-templated steroid hormone mediated signaling pathway positive regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription initiation from RNA polymerase II promoter intracellular receptor signaling pathway ornithine metabolic process lipid metabolic process acyl-CoA metabolic process xenobiotic metabolic process establishment of tissue polarity sex differentiation blood coagulation negative regulation of cell proliferation response to glucose regulation of gastrulation regulation of lipid metabolic process signal transduction involved in regulation of gene expression cell differentiation negative regulation of cell growth regulation of microvillus assembly negative regulation of protein import into nucleus, translocation response to drug negative regulation of tyrosine phosphorylation of Stat5 protein glucose homeostasis negative regulation of sequence-specific DNA binding transcription factor activity cell-cell junction organization positive regulation of gluconeogenesis positive regulation of fatty acid biosynthetic process negative regulation of mitotic cell cycle positive regulation of transcription from RNA polymerase II promoter regulation of insulin secretion response to cAMP lipid homeostasis phospholipid homeostasis SMAD protein signal transduction triglyceride homeostasis negative regulation of activation of JAK2 kinase activity positive regulation of cholesterol homeostasis transcription from RNA polymerase II promoter
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