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Product Details
PA5-41478
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide directed towards the middle region of human ONECUT1
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2576786
Product Specific Information
Peptide sequence: ITISQQLGLE LSTVSNFFMN ARRRSLDKWQ DEGSSNSGNS SSSSSTCTKA
Sequence homology: Cow: 93%; Dog: 100%; Horse: 100%; Human: 100%; Mouse: 86%; Pig: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 79%
Target Information
Hepatocyte nuclear factor 6 is a CUT homeobox family protein which is a transcription factor and contains a CUT DNA-binding domain and a homeobox DNA-binding domain. It is an upstream regulator of several genes involved in the pathogenesis of maturity-onset diabetes of the young. HNF6 is a ligand of the FOXM1 transcription factor network. HNF6, along with HNF4, controls gene expression in the liver. The expression levels of HNF6 and HNF4 rise steadily during development and that up- or down regulation of HNF6 and HNF4 expression generate premature or delayed expression of the g6pc gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Hepatocyte nuclear factor 6; hepatocyte nuclear factor 6, alpha; HNF-6; One cut domain family member 1; One cut homeobox 1
Gene Aliases: HNF-6; HNF6; HNF6A; ONECUT1
UniProt ID: (Human) Q9UBC0
Entrez Gene ID: (Human) 3175
liver development
regulation of cell-matrix adhesion
epithelial cell development
glucose metabolic process
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
Notch signaling pathway
endoderm development
cell differentiation
B cell differentiation
positive regulation of cell migration
negative regulation of transforming growth factor beta receptor signaling pathway
endocrine pancreas development
cilium assembly
cell fate commitment
positive regulation of transcription from RNA polymerase II promoter
spleen development
system development
Performance Guarantee
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