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Proteintech
HNMT Polyclonal Antibody
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Product Details
11874-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
HNMT Fusion Protein Ag2462 (1-292 aa encoded by BC020677)
Conjugate
Form
Liquid
Concentration
0.45 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MASSMRSLF SDHGKYVESF RRFLNHSTEH QCMQEFMDKK LPGIIGRIGD TKSEIKILSI GGGAGEIDLQ ILSKVQAQYP GVCINNEVVE PSAEQIAKYK ELVAKTSNLE NVKFAWHKET SSEYQSRMLE KKELQKWDFI HMIQMLYYVK DIPATLKFFH SLLGTNAKML IIVVSGSSGW DKLWKKYGSR FPQDDLCQYI TSDDLTQMLD NLGLKYECYD LLSTMDISDC FIDGDENGDL LWDFLTETCN FNATAPPDLR AELGKDLQEP EFSAKKEGKV LFNNTLSFIV IEA (1-292 aa encoded by BC020677)
Target Information
In mammals, histamine is metabolized by two major pathways: N(tau)-methylation via histamine N-methyltransferase and oxidative deamination via diamine oxidase. HNMT is the first enzyme which is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. In the mammalian brain, the neurotransmitter activity of histamine is controlled by N(tau)-methylation as diamine oxidase is not found in the central nervous system. A common genetic polymorphism affects the activity levels of this gene product in red blood cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Histamine N-methyltransferase; HMT
Gene Aliases: 1500031F01Rik; AI788969; HMT; HNMT; HNMT-S1; HNMT-S2; MRT51
UniProt ID: (Human) P50135, (Mouse) Q91VF2, (Rat) Q01984
Entrez Gene ID: (Human) 3176, (Mouse) 140483, (Rat) 81676
regulation of neurotransmitter levels
brain development
methylation
positive regulation of protein targeting to mitochondrion
histamine catabolic process
response to tumor cell
histidine catabolic process
hyperosmotic response
respiratory gaseous exchange
response to amine
response to immobilization stress
response to cocaine
response to glucocorticoid
response to interleukin-1
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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