Proteintech

HNRNPA1 Polyclonal Antibody

HNRNPA1 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 11

HNRNPA1 Antibody (11176-1-AP) in ICC/IF

Immunofluorescent analysis of ( 4% PFA ) fixed HeLa cells using 11176-1-AP (HNRNPA1 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

HNRNPA1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Product Image Gallery

Product Details

11176-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:5,000-1:50,000

View 26 publications 26 publications

Immunohistochemistry (IHC)

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:50-1:500

View 6 publications 6 publications

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Pig

Published species

Human, Mouse, Pig

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

HNRNPA1 Fusion Protein Ag1656 (1-320 aa encoded by BC009600)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.16 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MSKSESPKE PEQLRKLFIG GLSFETTDES LRSHFEQWGT LTDCVVMRDP NTKRSRGFGF VTYATVEEVD AAMNARPHKV DGRVVEPKRA VSREDSQRPG AHLTVKKIFV GGIKEDTEEH HLRDYFEQYG KIEVIEIMTD RGSGKKRGFA FVTFDDHDSV DKIVIQKYHT VNGHNCEVRK ALSKQEMASA SSSQRGRSGS GNFGGGRGGG FGGNDNFGRG GNFSGRGGFG GSRGGGGYGG SGDGYNGFGN DGSNFGGGGS YNDFGNYNNQ SSNFGPMKGG NFGGRSSGPY GGGGQYFAKP RNQGGYGGSS SSSSYGSGRR F (1-320 aa encoded by BC009600)

Target Information

HnRNP A1 belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre mRNAs in the nucleus and appear to influence pre mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. hnRNP A1 has two repeats of quasi RRM domains that bind to RNAs. It is one of the most abundant core proteins of hnRNP complexes and it is localized to the nucleoplasm. This protein, along with other hnRNP proteins, is exported from the nucleus, probably bound to mRNA, and is immediately re imported.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

A splicing silencer in SMN2 intron 6 is critical in spinal muscular atrophy.

Human molecular genetics

Wang L,Ji Y,Chen Y,Bai J,Gao P,Feng P

Mon Mar 06 00:00:00 UTC 2023

β-Hydroxybutyrate alleviates cartilage senescence through hnRNP A1-mediated up-regulation of PTEN.

Experimental gerontology

Xia G,Wen Z,Zhang L,Huang J,Wang X,Liang C,Cui X,Cao X,Wu S

Mon May 01 00:00:00 UTC 2023

N protein of PEDV plays chess game with host proteins by selective autophagy.

Autophagy

Zhai X,Kong N,Zhang Y,Song Y,Qin W,Yang X,Ye C,Ye M,Tong W,Liu C,Zheng H,Yu H,Zhang W,Yang X,Zhang G,Tong G,Shan T

Tue Aug 01 00:00:00 UTC 2023

N protein of PEDV plays chess game with host proteins by selective autophagy.

Autophagy

Zhai X,Kong N,Zhang Y,Song Y,Qin W,Yang X,Ye C,Ye M,Tong W,Liu C,Zheng H,Yu H,Zhang W,Yang X,Zhang G,Tong G,Shan T

Tue Aug 01 00:00:00 UTC 2023

N protein of PEDV plays chess game with host proteins by selective autophagy.

Autophagy

Zhai X,Kong N,Zhang Y,Song Y,Qin W,Yang X,Ye C,Ye M,Tong W,Liu C,Zheng H,Yu H,Zhang W,Yang X,Zhang G,Tong G,Shan T

Tue Aug 01 00:00:00 UTC 2023

N protein of PEDV plays chess game with host proteins by selective autophagy.

Autophagy

Zhai X,Kong N,Zhang Y,Song Y,Qin W,Yang X,Ye C,Ye M,Tong W,Liu C,Zheng H,Yu H,Zhang W,Yang X,Zhang G,Tong G,Shan T

Tue Aug 01 00:00:00 UTC 2023

Nuclear RNA binding regulates TDP-43 nuclear localization and passive nuclear export.

Cell reports

Duan L,Zaepfel BL,Aksenova V,Dasso M,Rothstein JD,Kalab P,Hayes LR

Tue Jul 19 00:00:00 UTC 2022

Kaempferol Can Reverse the 5-Fu Resistance of Colorectal Cancer Cells by Inhibiting PKM2-Mediated Glycolysis.

International journal of molecular sciences

Wu H,Du J,Li C,Li H,Guo H,Li Z

Thu Mar 24 00:00:00 UTC 2022

Rescue of mis-splicing of a common SLC26A4 mutant associated with sensorineural hearing loss by antisense oligonucleotides.

Molecular therapy. Nucleic acids

Feng P,Xu Z,Chen J,Liu M,Zhao Y,Wang D,Han L,Wang L,Wan B,Xu X,Li D,Shu Y,Hua Y

Tue Jun 14 00:00:00 UTC 2022

Position-dependent effects of hnRNP A1/A2 in SMN1/2 exon7 splicing.

Biochimica et biophysica acta. Gene regulatory mechanisms

Qiu J,Qu R,Lin M,Xu J,Zhu Q,Zhang Z,Sun J

Tue Nov 01 00:00:00 UTC 2022

The hnRNPK/A1/R/U Complex Regulates Gene Transcription and Translation and is a Favorable Prognostic Biomarker for Human Colorectal Adenocarcinoma.

Frontiers in oncology

Li Y,Wang H,Wan J,Ma Q,Qi Y,Gu Z

Tue Jul 26 00:00:00 UTC 2022

The hnRNPK/A1/R/U Complex Regulates Gene Transcription and Translation and is a Favorable Prognostic Biomarker for Human Colorectal Adenocarcinoma.

Frontiers in oncology

Li Y,Wang H,Wan J,Ma Q,Qi Y,Gu Z

Tue Jul 26 00:00:00 UTC 2022

Physiological tissue-specific and age-related reduction of mouse TDP-43 levels is regulated by epigenetic modifications.

Disease models & mechanisms

Pacetti M,De Conti L,Marasco LE,Romano M,Rashid MM,Nubiè M,Baralle FE,Baralle M

Fri Apr 01 00:00:00 UTC 2022

An APEX2 proximity ligation method for mapping interactions with the nuclear lamina.

The Journal of cell biology

Tran JR,Paulson DI,Moresco JJ,Adam SA,Yates JR,Goldman RD,Zheng Y

Mon Jan 04 00:00:00 UTC 2021

An APEX2 proximity ligation method for mapping interactions with the nuclear lamina.

The Journal of cell biology

Tran JR,Paulson DI,Moresco JJ,Adam SA,Yates JR,Goldman RD,Zheng Y

Mon Jan 04 00:00:00 UTC 2021

Profiling PRMT methylome reveals roles of hnRNPA1 arginine methylation in RNA splicing and cell growth.

Nature communications

Li WJ,He YH,Yang JJ,Hu GS,Lin YA,Ran T,Peng BL,Xie BL,Huang MF,Gao X,Huang HH,Zhu HH,Ye F,Liu W

Mon Mar 29 00:00:00 UTC 2021

Compensatory expression regulation of highly homologous proteins HNRNPA1 and HNRNPA2.

Turkish journal of biology = Turk biyoloji dergisi

Chang Y,Lu X,Qiu J

Thu Apr 29 00:00:00 UTC 2021

In vivo structural characterization of the SARS-CoV-2 RNA genome identifies host proteins vulnerable to repurposed drugs.

Cell

Sun L,Li P,Ju X,Rao J,Huang W,Ren L,Zhang S,Xiong T,Xu K,Zhou X,Gong M,Miska E,Ding Q,Wang J,Zhang QC

Thu Apr 01 00:00:00 UTC 2021

hnRNPM deficiency leads to cognitive deficits via disrupting synaptic plasticity.

Neuroscience letters

Akinyemi AR,Li D,Zhang J,Liu Q

Fri Apr 23 00:00:00 UTC 2021

Kaempferol Reverses Aerobic Glycolysis via miR-339-5p-Mediated PKM Alternative Splicing in Colon Cancer Cells.

Journal of agricultural and food chemistry

Wu H,Cui M,Li C,Li H,Dai Y,Cui K,Li Z

Wed Mar 17 00:00:00 UTC 2021

Esculetin inhibits endometrial cancer proliferation and promotes apoptosis via hnRNPA1 to downregulate BCLXL and XIAP.

Cancer letters

Jiang R,Su G,Chen X,Chen S,Li Q,Xie B,Zhao Y

Wed Sep 01 00:00:00 UTC 2021

Esculetin inhibits endometrial cancer proliferation and promotes apoptosis via hnRNPA1 to downregulate BCLXL and XIAP.

Cancer letters

Jiang R,Su G,Chen X,Chen S,Li Q,Xie B,Zhao Y

Wed Sep 01 00:00:00 UTC 2021

Esculetin inhibits endometrial cancer proliferation and promotes apoptosis via hnRNPA1 to downregulate BCLXL and XIAP.

Cancer letters

Jiang R,Su G,Chen X,Chen S,Li Q,Xie B,Zhao Y

Wed Sep 01 00:00:00 UTC 2021

Novel Non-Coding Transcript in NR4A3 Locus, LncNR4A3, Regulates RNA Processing Machinery Proteins and NR4A3 Expression.

Frontiers in oncology

Congrains A,Niemann FS,Duarte ADSS,Ferro KPV,Olalla-Saad ST

Fri Dec 18 00:00:00 UTC 2020

Transcriptome profiling reveals the high incidence of hnRNPA1 exon 8 inclusion in chronic myeloid leukemia.

Journal of advanced research

Li SQ,Liu J,Zhang J,Wang XL,Chen D,Wang Y,Xu YM,Huang B,Lin J,Li J,Wang XZ

Wed Jul 01 00:00:00 UTC 2020

Long Non-coding RNA HOTAIR Function as a Competing Endogenous RNA for miR-149-5p to Promote the Cell Growth, Migration, and Invasion in Non-small Cell Lung Cancer.

Frontiers in oncology

Li H,Cui Z,Lv X,Li J,Gao M,Yang Z,Bi Y,Zhang Z,Wang S,Li S,Zhou B,Yin Z

Wed Oct 28 00:00:00 UTC 2020

A novel miR-206/hnRNPA1/PKM2 axis reshapes the Warburg effect to suppress colon cancer growth.

Biochemical and biophysical research communications

Fu R,Yang P,Amin S,Li Z

Thu Oct 22 00:00:00 UTC 2020

Enzymatic degradation of RNA causes widespread protein aggregation in cell and tissue lysates.

EMBO reports

Aarum J,Cabrera CP,Jones TA,Rajendran S,Adiutori R,Giovannoni G,Barnes MR,Malaspina A,Sheer D

Mon Oct 05 00:00:00 UTC 2020

E3 ligase ZFP91 inhibits Hepatocellular Carcinoma Metabolism Reprogramming by regulating PKM splicing.

Theranostics

Chen D,Wang Y,Lu R,Jiang X,Chen X,Meng N,Chen M,Xie S,Yan GR

Wed May 19 00:00:00 UTC 2021

Zc3h13 Regulates Nuclear RNA m⁶A Methylation and Mouse Embryonic Stem Cell Self-Renewal.

Molecular cell

Wen J,Lv R,Ma H,Shen H,He C,Wang J,Jiao F,Liu H,Yang P,Tan L,Lan F,Shi YG,He C,Shi Y,Diao J

Thu Mar 15 00:00:00 UTC 2018

Zc3h13 Regulates Nuclear RNA m⁶A Methylation and Mouse Embryonic Stem Cell Self-Renewal.

Molecular cell

Wen J,Lv R,Ma H,Shen H,He C,Wang J,Jiao F,Liu H,Yang P,Tan L,Lan F,Shi YG,He C,Shi Y,Diao J

Thu Mar 15 00:00:00 UTC 2018

A Peptide Encoded by a Putative lncRNA HOXB-AS3 Suppresses Colon Cancer Growth.

Molecular cell

Huang JZ,Chen M,Chen D,Gao XC,Zhu S,Huang H,Hu M,Zhu H,Yan GR

Thu Oct 05 00:00:00 UTC 2017

A Peptide Encoded by a Putative lncRNA HOXB-AS3 Suppresses Colon Cancer Growth.

Molecular cell

Huang JZ,Chen M,Chen D,Gao XC,Zhu S,Huang H,Hu M,Zhu H,Yan GR

Thu Oct 05 00:00:00 UTC 2017

Long-term artificial selection reveals a role of TCTP in autophagy in mammalian cells.

Molecular biology and evolution

Chen K,Huang C,Yuan J,Cheng H,Zhou R

Fri Aug 01 00:00:00 UTC 2014

Long-term artificial selection reveals a role of TCTP in autophagy in mammalian cells.

Molecular biology and evolution

Chen K,Huang C,Yuan J,Cheng H,Zhou R

Fri Aug 01 00:00:00 UTC 2014

HnRNP A1/A2 and SF2/ASF regulate alternative splicing of interferon regulatory factor-3 and affect immunomodulatory functions in human non-small cell lung cancer cells.

PloS one

Guo R,Li Y,Ning J,Sun D,Lin L,Liu X

Mon Dec 09 00:00:00 UTC 2013

HnRNP A1/A2 and SF2/ASF regulate alternative splicing of interferon regulatory factor-3 and affect immunomodulatory functions in human non-small cell lung cancer cells.

PloS one

Guo R,Li Y,Ning J,Sun D,Lin L,Liu X

Mon Dec 09 00:00:00 UTC 2013

HnRNP A1/A2 and SF2/ASF regulate alternative splicing of interferon regulatory factor-3 and affect immunomodulatory functions in human non-small cell lung cancer cells.

PloS one

Guo R,Li Y,Ning J,Sun D,Lin L,Liu X

Mon Dec 09 00:00:00 UTC 2013

HnRNP A1/A2 and SF2/ASF regulate alternative splicing of interferon regulatory factor-3 and affect immunomodulatory functions in human non-small cell lung cancer cells.

PloS one

Guo R,Li Y,Ning J,Sun D,Lin L,Liu X

Mon Dec 09 00:00:00 UTC 2013

Two-dimensional liquid chromatography-tandem mass spectrometry coupled with isobaric tags for relative and absolute quantification (iTRAQ) labeling approach revealed first proteome profiles of pulmonary alveolar macrophages infected with porcine reproductive and respiratory syndrome virus.

Journal of proteome research

Lu Q,Bai J,Zhang L,Liu J,Jiang Z,Michal JJ,He Q,Jiang P

Fri May 04 00:00:00 UTC 2012

Journal of proteome research

Lu Q,Bai J,Zhang L,Liu J,Jiang Z,Michal JJ,He Q,Jiang P

Fri May 04 00:00:00 UTC 2012

Journal of proteome research

Lu Q,Bai J,Zhang L,Liu J,Jiang Z,Michal JJ,He Q,Jiang P

Fri May 04 00:00:00 UTC 2012

Journal of proteome research

Lu Q,Bai J,Zhang L,Liu J,Jiang Z,Michal JJ,He Q,Jiang P

Fri May 04 00:00:00 UTC 2012

Resveratrol, by modulating RNA processing factor levels, can influence the alternative splicing of pre-mRNAs.

PloS one

Markus MA,Marques FZ,Morris BJ

Mon Apr 23 00:00:00 UTC 2012

Resveratrol, by modulating RNA processing factor levels, can influence the alternative splicing of pre-mRNAs.

PloS one

Markus MA,Marques FZ,Morris BJ

Mon Apr 23 00:00:00 UTC 2012

Resveratrol, by modulating RNA processing factor levels, can influence the alternative splicing of pre-mRNAs.

PloS one

Markus MA,Marques FZ,Morris BJ

Mon Apr 23 00:00:00 UTC 2012

Resveratrol, by modulating RNA processing factor levels, can influence the alternative splicing of pre-mRNAs.

PloS one

Markus MA,Marques FZ,Morris BJ

Mon Apr 23 00:00:00 UTC 2012

Bioinformatics

Protein Aliases: HDP-1; Helix-destabilizing protein; Heterogeneous nuclear ribonucleoprotein A1; heterogeneous nuclear ribonucleoprotein A1B protein; heterogeneous nuclear ribonucleoprotein B2 protein; heterogeneous nuclear ribonucleoprotein core protein A1; hnRNP A1; hnRNP A1-like 3; hnRNP core protein A1; hnRNP core protein A1-like 3; hnRNP I; HNRNP-I; HNRNPI; HNRPA1MGC102835; HNRPI; MGC102835; nuclear ribonucleoprotein particle A1 protein; pPTB; PTB; PTB-1; PTB-T; PTB2; PTB3; PTB4; putative heterogeneous nuclear ribonucleoprotein A1-like 3; RP11-78J21.1; single-strand DNA-binding protein UP1; Single-strand RNA-binding protein; Single-strand-binding protein; Topoisomerase-inhibitor suppressed

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Gene Aliases: ALS19; ALS20; Fli-2; Hdp; HDP-1; hnRNP A1; hnRNP-A1; HNRNPA1; HNRPA1; HNRPA1L3; IBMPFD3; ROA1; Tis; UP 1

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UniProt ID: (Human) P09651, (Mouse) P49312

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Entrez Gene ID: (Human) 3178, (Pig) 768103, (Mouse) 15382

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Function(s)

nucleotide binding single-stranded DNA binding RNA binding single-stranded RNA binding protein binding poly(A) RNA binding telomeric repeat-containing RNA binding G-rich strand telomeric DNA binding nucleic acid binding

Process(es)

mRNA splicing, via spliceosome mRNA processing RNA export from nucleus fibroblast growth factor receptor signaling pathway gene expression viral process negative regulation of telomere maintenance via telomerase positive regulation of telomere maintenance via telomerase mRNA transport nuclear export nuclear import alternative mRNA splicing, via spliceosome transport RNA splicing

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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HNRNPA1 Polyclonal Antibody

HNRNPA1 Antibody (11176-1-AP) in ICC/IF

Product Details

11176-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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