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HNRNPC Polyclonal Antibody

HNRNPC Antibody in Immunocytochemistry (ICC/IF)

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HNRNPC Antibody (11760-1-AP) in ICC/IF

Immunofluorescent analysis of ( 4% PFA ) fixed HeLa cells using 11760-1-AP (HNRNPC antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

HNRNPC Antibody in Immunohistochemistry (Paraffin) (IHC (P))

HNRNPC Antibody in Flow Cytometry (Flow)

HNRNPC Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

11760-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:5,000-1:50,000

View 14 publications 14 publications

Immunohistochemistry (IHC)

View 6 publications 6 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:50-1:500

View 1 publication 1 publication

Flow Cytometry (Flow)

0.2 µg/1x10^6 cells

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

HNRNPC Fusion Protein Ag2356 (1-293 aa encoded by BC003394)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.13 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MASNVTNKT DPRSMNSRVF IGNLNTLVVK KSDVEAIFSK YGKIVGCSVH KGFAFVQYVN ERNARAAVAG EDGRMIAGQV LDINLAAEPK VNRGKAGVKR SAAEMYGSSF DLDYDFQRDY YDRMYSYPAR VPPPPPIARA VVPSKRQRVS GNTSRRGKSG FNSKSGQRGS SKSGKLKGDD LQAIKKELTQ IKQKVDSLLE NLEKIEKEQS KQAVEMKNDK SEEEQSSSSV KKDETNVKME SEGGADDSAE EGDLLDDDDN EDRGDDQLEL IKDDEKEAEE GEDDRDSANG EDDS (1-293 aa encoded by BC003394)

Target Information

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene can act as a tetramer and is involved in the assembly of 40S hnRNP particles. Multiple transcript variants encoding at least two different isoforms have been described for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

The miR-27a-3p/FTO axis modifies hypoxia-induced malignant behaviors of glioma cells.

Acta biochimica et biophysica Sinica

Du P,Meng L,Liao X,Liu Y,Mo X,Gong M,Liao Y

Wed Jan 25 00:00:00 UTC 2023

LncRNA BC promotes lung adenocarcinoma progression by modulating IMPAD1 alternative splicing.

Clinical and translational medicine

Chen QW,Cai QQ,Yang Y,Dong S,Liu YY,Chen ZY,Kang CL,Qi B,Dong YW,Wu W,Zhuang LP,Shen YH,Meng ZQ,Wu XZ

Sun Jan 01 00:00:00 UTC 2023

MS0621, a novel small-molecule modulator of Ewing sarcoma chromatin accessibility, interacts with an RNA-associated macromolecular complex and influences RNA splicing.

Frontiers in oncology

Vital T,Wali A,Butler KV,Xiong Y,Foster JP,Marcel SS,McFadden AW,Nguyen VU,Bailey BM,Lamb KN,James LI,Frye SV,Mosely AL,Jin J,Pattenden SG,Davis IJ

Mon Apr 22 00:00:00 UTC 2024

A splicing silencer in SMN2 intron 6 is critical in spinal muscular atrophy.

Human molecular genetics

Wang L,Ji Y,Chen Y,Bai J,Gao P,Feng P

Mon Mar 06 00:00:00 UTC 2023

Alternative transcribed 3' isoform of long non-coding RNA Malat1 inhibits mouse retinal oxidative stress.

iScience

Ghanam AR,Ke S,Wang S,Elgendy R,Xie C,Wang S,Zhang R,Wei M,Liu W,Cao J,Zhang Y,Zhang Z,Xue T,Zheng Y,Song X

Fri Jan 20 00:00:00 UTC 2023

Bioinformatics-based analysis of SUMOylation-related genes in hepatocellular carcinoma reveals a role of upregulated SAE1 in promoting cell proliferation.

Open medicine (Warsaw, Poland)

Liu Y,Wang X,Zeng X,Wu Y,Liu X,Tan J,Li X

Fri Jul 22 00:00:00 UTC 2022

Essential m⁶A Methylation Regulator HNRNPC Serves as a Targetable Biomarker for Papillary Renal Cell Carcinoma.

Journal of oncology

Wu J,Wei Y,Miao C,Wang S,Wang X,Wang Z

Sat Sep 16 00:00:00 UTC 2023

Four m6A RNA Methylation Gene Signatures and Their Prognostic Values in Lung Adenocarcinoma.

Technology in cancer research & treatment

Wang Y,Zhao X,Li J,Wang X,Hu W,Zhang X

Tue Apr 05 00:00:00 UTC 2022

Alternative polyadenylation by sequential activation of distal and proximal PolyA sites.

Nature structural & molecular biology

Tang P,Yang Y,Li G,Huang L,Wen M,Ruan W,Guo X,Zhang C,Zuo X,Luo D,Xu Y,Fu XD,Zhou Y

Sat Jan 01 00:00:00 UTC 2022

Nuclear RNA transcript levels modulate nucleocytoplasmic distribution of ALS/FTD-associated protein FUS.

Scientific reports

Tsai YL,Mu YC,Manley JL

Tue May 17 00:00:00 UTC 2022

Systematic analysis of the expression profile and prognostic significance of m6A regulators and PD-L1 in hepatocellular carcinoma.

Discover oncology

Kong F,Wang K,Wang L

Fri Nov 25 00:00:00 UTC 2022

The hnRNPK/A1/R/U Complex Regulates Gene Transcription and Translation and is a Favorable Prognostic Biomarker for Human Colorectal Adenocarcinoma.

Frontiers in oncology

Li Y,Wang H,Wan J,Ma Q,Qi Y,Gu Z

Tue Jul 26 00:00:00 UTC 2022

Sequence-dependent recruitment of SRSF1 and SRSF7 to intronless lncRNA NKILA promotes nuclear export via the TREX/TAP pathway.

Nucleic acids research

Khan M,Hou S,Azam S,Lei H

Mon Jun 21 00:00:00 UTC 2021

NEAT1 is essential for metabolic changes that promote breast cancer growth and metastasis.

Cell metabolism

Park MK,Zhang L,Min KW,Cho JH,Yeh CC,Moon H,Hormaechea-Agulla D,Mun H,Ko S,Lee JW,Jathar S,Smith AS,Yao Y,Giang NT,Vu HH,Yan VC,Bridges MC,Kourtidis A,Muller F,Chang JH,Song SJ,Nakagawa S,Hirose T,Yoon JH,Song MS

Tue Dec 07 00:00:00 UTC 2021

hnRNPM deficiency leads to cognitive deficits via disrupting synaptic plasticity.

Neuroscience letters

Akinyemi AR,Li D,Zhang J,Liu Q

Fri Apr 23 00:00:00 UTC 2021

Analysis and validation of m6A regulatory network: a novel circBACH2/has-miR-944/HNRNPC axis in breast cancer progression.

Journal of translational medicine

Lv W,Tan Y,Xiong M,Zhao C,Wang Y,Wu M,Wu Y,Zhang Q

Fri Dec 24 00:00:00 UTC 2021

METTL3 regulates heterochromatin in mouse embryonic stem cells.

Nature

Xu W,Li J,He C,Wen J,Ma H,Rong B,Diao J,Wang L,Wang J,Wu F,Tan L,Shi YG,Shi Y,Shen H

Mon Mar 01 00:00:00 UTC 2021

Expression and Prognostic Significance of m6A-Related Genes in Lung Adenocarcinoma.

Medical science monitor : international medical journal of experimental and clinical research

Zhang Y,Liu X,Liu L,Li J,Hu Q,Sun R

Sat Feb 22 00:00:00 UTC 2020

M6A RNA Methylation Regulator HNRNPC Contributes to Tumorigenesis and Predicts Prognosis in Glioblastoma Multiforme.

Frontiers in oncology

Wang LC,Chen SH,Shen XL,Li DC,Liu HY,Ji YL,Li M,Yu K,Yang H,Chen JJ,Qin CZ,Luo MM,Lin QX,Lv QL

Tue Nov 03 00:00:00 UTC 2020

M6A RNA Methylation Regulator HNRNPC Contributes to Tumorigenesis and Predicts Prognosis in Glioblastoma Multiforme.

Frontiers in oncology

Wang LC,Chen SH,Shen XL,Li DC,Liu HY,Ji YL,Li M,Yu K,Yang H,Chen JJ,Qin CZ,Luo MM,Lin QX,Lv QL

Tue Nov 03 00:00:00 UTC 2020

An investigation into the cytotoxic effects of 13-acetoxysarcocrassolide from the soft coral Sarcophyton crassocaule on bladder cancer cells.

Marine drugs

Su CC,Su JH,Lin JJ,Chen CC,Hwang WI,Huang HH,Wu YJ

Thu Dec 01 00:00:00 UTC 2011

An investigation into the cytotoxic effects of 13-acetoxysarcocrassolide from the soft coral Sarcophyton crassocaule on bladder cancer cells.

Marine drugs

Su CC,Su JH,Lin JJ,Chen CC,Hwang WI,Huang HH,Wu YJ

Thu Dec 01 00:00:00 UTC 2011

Bioinformatics

Protein Aliases: Heterogeneous nuclear ribonucleoproteins C1/C2; hnRNP C1/C2; nuclear ribonucleoprotein particle C1 protein; nuclear ribonucleoprotein particle C2 protein

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Gene Aliases: C1; C2; HNRNP; HNRNPC; HNRPC; SNRPC

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UniProt ID: (Human) P07910

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Entrez Gene ID: (Human) 3183

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Function(s)

nucleotide binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II distal enhancer sequence-specific DNA binding RNA binding mRNA 3'-UTR binding protein binding poly(U) RNA binding nucleosomal DNA binding identical protein binding poly(A) RNA binding telomerase RNA binding N6-methyladenosine-containing RNA binding

Process(es)

mRNA splicing, via spliceosome osteoblast differentiation RNA splicing gene expression protein sumoylation negative regulation of telomere maintenance via telomerase ATP-dependent chromatin remodeling 3'-UTR-mediated mRNA stabilization

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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HNRNPC Polyclonal Antibody

HNRNPC Antibody (11760-1-AP) in ICC/IF

Product Details

11760-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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