Proteintech

HNRNPD Polyclonal Antibody

HNRNPD Antibody in Immunocytochemistry (ICC/IF)

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HNRNPD Antibody (12770-1-AP) in ICC/IF

Immunofluorescent analysis of HepG2 cells, using HNRNPD antibody 12770-1-AP at 1:50 dilution and Rhodamine-labeled goat anti-rabbit IgG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).

HNRNPD Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Product Details

12770-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 16 publications 16 publications

Immunohistochemistry (IHC)

View 5 publications 5 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

1:50-1:500

View 3 publications 3 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

HNRNPD Fusion Protein Ag3458 (1-306 aa encoded by BC026015)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.27 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MSEEQFGGD GAAAAATAAV GGSAGEQEGA MVAATQGAAA AAGSGAGTGG GTASGGTEGG SAESEGAKID ASKNEEDEGH SNSSPRHSEA ATAQREEWKM FIGGLSWDTT KKDLKDYFSK FGEVVDCTLK LDPITGRSRG FGFVLFKESE SVDKVMDQKE HKLNGKVIDP KRAKAMKTKE PVKKIFVGGL SPDTPEEKIR EYFGGFGEVE SIELPMDNKT NKRRGFCFIT FKEEEPVKKI MEKKYHNVGL SKCEIKVAMS KEQYQQQQQW GSRGGFAGRA RGRGGDQQSG YGKVSRRGGH QNSYKPY (1-306 aa encoded by BC026015)

Target Information

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are nucleic acid binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It localizes to both the nucleus and the cytoplasm. This protein is implicated in the regulation of mRNA stability. Alternative splicing of this gene results in four transcript variants.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

LncRNA BC promotes lung adenocarcinoma progression by modulating IMPAD1 alternative splicing.

Clinical and translational medicine

Chen QW,Cai QQ,Yang Y,Dong S,Liu YY,Chen ZY,Kang CL,Qi B,Dong YW,Wu W,Zhuang LP,Shen YH,Meng ZQ,Wu XZ

Sun Jan 01 00:00:00 UTC 2023

Targeting lncRNA DDIT4-AS1 Sensitizes Triple Negative Breast Cancer to Chemotherapy via Suppressing of Autophagy.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Jiang T,Zhu J,Jiang S,Chen Z,Xu P,Gong R,Zhong C,Cheng Y,Sun X,Yi W,Yang J,Zhou W,Cheng Y

Thu Jun 01 00:00:00 UTC 2023

Characterization of the protein expression and localization of hnRNP family members during murine spermatogenesis.

Asian journal of andrology

Wang XL,Li JM,Yuan SQ

Fri Apr 28 00:00:00 UTC 2023

Characterization of the protein expression and localization of hnRNP family members during murine spermatogenesis.

Asian journal of andrology

Wang XL,Li JM,Yuan SQ

Fri Apr 28 00:00:00 UTC 2023

10-Hydroxydec-2-Enoic Acid Reduces Hydroxyl Free Radical-Induced Damage to Vascular Smooth Muscle Cells by Rescuing Protein and Energy Metabolism.

Frontiers in nutrition

Fan P,Sha F,Ma C,Wei Q,Zhou Y,Shi J,Fu J,Zhang L,Han B,Li J

Sat Jul 16 00:00:00 UTC 2022

The lncRNA THOR interacts with and stabilizes hnRNPD to promote cell proliferation and metastasis in breast cancer.

Oncogene

Hu H,Zhang H,Xing Y,Zhou Y,Chen J,Li C,Xu J,Guo Y,Wang J,He Q,Liu X,Sheng J,Song E,Wu Y,Huang H

Thu Dec 01 00:00:00 UTC 2022

The lncRNA THOR interacts with and stabilizes hnRNPD to promote cell proliferation and metastasis in breast cancer.

Oncogene

Hu H,Zhang H,Xing Y,Zhou Y,Chen J,Li C,Xu J,Guo Y,Wang J,He Q,Liu X,Sheng J,Song E,Wu Y,Huang H

Thu Dec 01 00:00:00 UTC 2022

The hnRNPK/A1/R/U Complex Regulates Gene Transcription and Translation and is a Favorable Prognostic Biomarker for Human Colorectal Adenocarcinoma.

Frontiers in oncology

Li Y,Wang H,Wan J,Ma Q,Qi Y,Gu Z

Tue Jul 26 00:00:00 UTC 2022

Genome-wide analysis of pseudogenes reveals HBBP1's human-specific essentiality in erythropoiesis and implication in β-thalassemia.

Developmental cell

Ma Y,Liu S,Gao J,Chen C,Zhang X,Yuan H,Chen Z,Yin X,Sun C,Mao Y,Zhou F,Shao Y,Liu Q,Xu J,Cheng L,Yu D,Li P,Yi P,He J,Geng G,Guo Q,Si Y,Zhao H,Li H,Banes GL,Liu H,Nakamura Y,Kurita R,Huang Y,Wang X,Wang F,Fang G,Engel JD,Shi L,Zhang YE,Yu J

Mon Feb 22 00:00:00 UTC 2021

hnRNPM deficiency leads to cognitive deficits via disrupting synaptic plasticity.

Neuroscience letters

Akinyemi AR,Li D,Zhang J,Liu Q

Fri Apr 23 00:00:00 UTC 2021

Effects of ribosomal associated protein hnRNP D in gemcitabine-resistant pancreatic cancer.

Biochemical and biophysical research communications

Wang C,Huang H

Fri Nov 19 00:00:00 UTC 2021

Effects of ribosomal associated protein hnRNP D in gemcitabine-resistant pancreatic cancer.

Biochemical and biophysical research communications

Wang C,Huang H

Fri Nov 19 00:00:00 UTC 2021

lncRNA RMST Suppressed GBM Cell Mitophagy through Enhancing FUS SUMOylation.

Molecular therapy. Nucleic acids

Liu C,Peng Z,Li P,Fu H,Feng J,Zhang Y,Liu T,Liu Y,Liu Q,Liu Q,Li D,Wu M

Fri Mar 06 00:00:00 UTC 2020

A Comparative Quantitative Proteomic Analysis of HCMV-Infected Cells Highlights pUL138 as a Multifunctional Protein.

Molecules (Basel, Switzerland)

Li Y,Shang W,Xiao G,Zhang LK,Zheng C

Thu May 28 00:00:00 UTC 2020

Angiotensin II contributes to intratumoral immunosuppressionvia induction of PD-L1 expression in non-small cell lung carcinoma.

International immunopharmacology

Yang K,Zhou J,Chen Y,Chen Y,Chen L,Zhang P,Ma L,Jiang Z,Bian J,Yin W

Wed Jul 01 00:00:00 UTC 2020

Enzymatic degradation of RNA causes widespread protein aggregation in cell and tissue lysates.

EMBO reports

Aarum J,Cabrera CP,Jones TA,Rajendran S,Adiutori R,Giovannoni G,Barnes MR,Malaspina A,Sheer D

Mon Oct 05 00:00:00 UTC 2020

Identification and Verification of Two Novel Differentially Expressed Proteins from Non-neoplastic Mucosa and Colorectal Carcinoma Via iTRAQ Combined with Liquid Chromatography-Mass Spectrometry.

Pathology oncology research : POR

Bai Y,Wang J,Gao Z,Dai E

Wed Apr 01 00:00:00 UTC 2020

Acetylation of Cytidine in mRNA Promotes Translation Efficiency.

Cell

Arango D,Sturgill D,Alhusaini N,Dillman AA,Sweet TJ,Hanson G,Hosogane M,Sinclair WR,Nanan KK,Mandler MD,Fox SD,Zengeya TT,Andresson T,Meier JL,Coller J,Oberdoerffer S

Thu Dec 13 00:00:00 UTC 2018

Acetylation of Cytidine in mRNA Promotes Translation Efficiency.

Cell

Arango D,Sturgill D,Alhusaini N,Dillman AA,Sweet TJ,Hanson G,Hosogane M,Sinclair WR,Nanan KK,Mandler MD,Fox SD,Zengeya TT,Andresson T,Meier JL,Coller J,Oberdoerffer S

Thu Dec 13 00:00:00 UTC 2018

Unraveling Molecular Differences of Gastric Cancer by Label-Free Quantitative Proteomics Analysis.

International journal of molecular sciences

Dai P,Wang Q,Wang W,Jing R,Wang W,Wang F,Azadzoi KM,Yang JH,Yan Z

Thu Jan 21 00:00:00 UTC 2016

Unraveling Molecular Differences of Gastric Cancer by Label-Free Quantitative Proteomics Analysis.

International journal of molecular sciences

Dai P,Wang Q,Wang W,Jing R,Wang W,Wang F,Azadzoi KM,Yang JH,Yan Z

Thu Jan 21 00:00:00 UTC 2016

Unraveling Molecular Differences of Gastric Cancer by Label-Free Quantitative Proteomics Analysis.

International journal of molecular sciences

Dai P,Wang Q,Wang W,Jing R,Wang W,Wang F,Azadzoi KM,Yang JH,Yan Z

Thu Jan 21 00:00:00 UTC 2016

Unraveling Molecular Differences of Gastric Cancer by Label-Free Quantitative Proteomics Analysis.

International journal of molecular sciences

Dai P,Wang Q,Wang W,Jing R,Wang W,Wang F,Azadzoi KM,Yang JH,Yan Z

Thu Jan 21 00:00:00 UTC 2016

Subcellular quantitative proteomic analysis reveals host proteins involved in human cytomegalovirus infection.

Biochimica et biophysica acta

Chai F,Li HY,Wang W,Zhu XJ,Li Y,Wang S,Guo L,Zhang LK,Xiao G

Sat Aug 01 00:00:00 UTC 2015

Subcellular quantitative proteomic analysis reveals host proteins involved in human cytomegalovirus infection.

Biochimica et biophysica acta

Chai F,Li HY,Wang W,Zhu XJ,Li Y,Wang S,Guo L,Zhang LK,Xiao G

Sat Aug 01 00:00:00 UTC 2015

Subcellular quantitative proteomic analysis reveals host proteins involved in human cytomegalovirus infection.

Biochimica et biophysica acta

Chai F,Li HY,Wang W,Zhu XJ,Li Y,Wang S,Guo L,Zhang LK,Xiao G

Sat Aug 01 00:00:00 UTC 2015

Subcellular quantitative proteomic analysis reveals host proteins involved in human cytomegalovirus infection.

Biochimica et biophysica acta

Chai F,Li HY,Wang W,Zhu XJ,Li Y,Wang S,Guo L,Zhang LK,Xiao G

Sat Aug 01 00:00:00 UTC 2015

Sequestration of multiple RNA recognition motif-containing proteins by C9orf72 repeat expansions.

Brain : a journal of neurology

Cooper-Knock J,Walsh MJ,Higginbottom A,Robin Highley J,Dickman MJ,Edbauer D,Ince PG,Wharton SB,Wilson SA,Kirby J,Hautbergue GM,Shaw PJ

Tue Jul 01 00:00:00 UTC 2014

Sequestration of multiple RNA recognition motif-containing proteins by C9orf72 repeat expansions.

Brain : a journal of neurology

Cooper-Knock J,Walsh MJ,Higginbottom A,Robin Highley J,Dickman MJ,Edbauer D,Ince PG,Wharton SB,Wilson SA,Kirby J,Hautbergue GM,Shaw PJ

Tue Jul 01 00:00:00 UTC 2014

Transportin 1 accumulates specifically with FET proteins but no other transportin cargos in FTLD-FUS and is absent in FUS inclusions in ALS with FUS mutations.

Acta neuropathologica

Neumann M,Valori CF,Ansorge O,Kretzschmar HA,Munoz DG,Kusaka H,Yokota O,Ishihara K,Ang LC,Bilbao JM,Mackenzie IR

Thu Nov 01 00:00:00 UTC 2012

Transportin 1 accumulates specifically with FET proteins but no other transportin cargos in FTLD-FUS and is absent in FUS inclusions in ALS with FUS mutations.

Acta neuropathologica

Neumann M,Valori CF,Ansorge O,Kretzschmar HA,Munoz DG,Kusaka H,Yokota O,Ishihara K,Ang LC,Bilbao JM,Mackenzie IR

Thu Nov 01 00:00:00 UTC 2012

Bioinformatics

Protein Aliases: ARE-binding protein AUFI, type A; AU-rich element RNA binding protein 1, 37kDa; AU-rich element RNA-binding factor 1; AU-rich element RNA-binding protein 1; heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa); Heterogeneous nuclear ribonucleoprotein D0; hnRNP D0; RNA binding protein p45AUF1

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Gene Aliases: AUF1; AUF1A; HNRNPD; hnRNPD0; HNRPD; P37

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UniProt ID: (Human) Q14103, (Mouse) Q60668, (Rat) Q9JJ54

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Entrez Gene ID: (Human) 3184, (Mouse) 11991, (Rat) 79256

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Function(s)

nucleotide binding AT DNA binding chromatin binding RNA binding protein binding transcription factor binding mRNA 3'-UTR AU-rich region binding telomeric DNA binding histone deacetylase binding poly(A) RNA binding nucleic acid binding DNA binding mRNA binding

Process(es)

nuclear-transcribed mRNA catabolic process, exonucleolytic nucleocytoplasmic transport regulation of circadian rhythm regulation of mRNA stability positive regulation of translation mRNA stabilization circadian regulation of translation mRNA splicing, via spliceosome liver development transcription, DNA-templated regulation of transcription, DNA-templated RNA processing RNA catabolic process gene expression response to fluoxetine cerebellum development positive regulation of transcription, DNA-templated response to calcium ion response to electrical stimulus 3'-UTR-mediated mRNA destabilization cellular response to amino acid stimulus cellular response to estradiol stimulus cellular response to nitric oxide response to rapamycin response to sodium phosphate cellular response to putrescine hepatocyte dedifferentiation rhythmic process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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HNRNPD Polyclonal Antibody

HNRNPD Antibody (12770-1-AP) in ICC/IF

Product Details

12770-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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