Proteintech

HNRNPU Polyclonal Antibody

HNRNPU Antibody in Immunocytochemistry (ICC/IF)

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HNRNPU Antibody (14599-1-AP) in ICC/IF

Immunofluorescent analysis of HeLa cells using 14599-1-AP (HNRNPU antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

HNRNPU Antibody in Immunoprecipitation (IP)

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Product Details

14599-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:4,000

View 14 publications 14 publications

Immunocytochemistry (ICC/IF)

1:20-1:200

View 1 publication 1 publication

Immunoprecipitation (IP)

0.5-4.0 µg

View 1 publication 1 publication

RNA Immunoprecipitation (RIP)

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

HNRNPU Fusion Protein Ag6141 (10-236 aa encoded by BC003621)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.62 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: KLKVSELKE ELKKRRLSDK GLKAELMERL QAALDDEEAG GRPAMEPGNG SLDLGGDSAG RSGAGLEQEA AAGGDEEEEE EEEEEEGISA LDGDQMELGE ENGAAGAADS GPMEEEEAAS EDENGDDQGF QEGEDELGDE EEGAGDENGH GEQQPQPPAT QQQQPQQQRG AAKEAAGKSS GPTSLFAVTV APPGARQGQQ QAGGDGKTEQ KGGDKKRGVK RPREDHGR (10-236 aa encoded by BC003621 )

Target Information

The protein encoded by this gene is a receptor for activated C-kinase (RACK) protein. The encoded protein has been shown to bind in vitro to activated protein kinase C beta I. In addition, this protein is a cutaneous T-cell lymphoma-associated antigen. Finally, the protein contains a bromodomain and two zinc fingers, and is thought to be a transcriptional regulator. Multiple transcript variants encoding several different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Human DUX4 and mouse Dux interact with STAT1 and broadly inhibit interferon-stimulated gene induction.

eLife

Spens AE,Sutliff NA,Bennett SR,Campbell AE,Tapscott SJ

Mon Apr 24 00:00:00 UTC 2023

p38-mediated FOXN3 phosphorylation modulates lung inflammation and injury through the NF-κB signaling pathway.

Nucleic acids research

Zhu X,Huang B,Zhao F,Lian J,He L,Zhang Y,Ji L,Zhang J,Yan X,Zeng T,Ma C,Liang Y,Zhang C,Lin J

Tue Mar 21 00:00:00 UTC 2023

p38-mediated FOXN3 phosphorylation modulates lung inflammation and injury through the NF-κB signaling pathway.

Nucleic acids research

Zhu X,Huang B,Zhao F,Lian J,He L,Zhang Y,Ji L,Zhang J,Yan X,Zeng T,Ma C,Liang Y,Zhang C,Lin J

Tue Mar 21 00:00:00 UTC 2023

Comparison of viral RNA-host protein interactomes across pathogenic RNA viruses informs rapid antiviral drug discovery for SARS-CoV-2.

Cell research

Zhang S,Huang W,Ren L,Ju X,Gong M,Rao J,Sun L,Li P,Ding Q,Wang J,Zhang QC

Sat Jan 01 00:00:00 UTC 2022

SRSF3 facilitates replication of influenza A virus via binding and promoting the transport of viral mRNA.

Veterinary microbiology

Zhao L,Li Y,Zhao Y,Liu Q,Lu Y,Ping J

Tue Mar 01 00:00:00 UTC 2022

Circulating Exosomal miR-493-3p Affects Melanocyte Survival and Function by Regulating Epidermal Dopamine Concentration in Segmental Vitiligo.

The Journal of investigative dermatology

Li D,Zhou T,She Q,Nie X,Liu Z,Pan R,Wei Y,Deng Y

Thu Dec 01 00:00:00 UTC 2022

Circulating Exosomal miR-493-3p Affects Melanocyte Survival and Function by Regulating Epidermal Dopamine Concentration in Segmental Vitiligo.

The Journal of investigative dermatology

Li D,Zhou T,She Q,Nie X,Liu Z,Pan R,Wei Y,Deng Y

Thu Dec 01 00:00:00 UTC 2022

Profiling PRMT methylome reveals roles of hnRNPA1 arginine methylation in RNA splicing and cell growth.

Nature communications

Li WJ,He YH,Yang JJ,Hu GS,Lin YA,Ran T,Peng BL,Xie BL,Huang MF,Gao X,Huang HH,Zhu HH,Ye F,Liu W

Mon Mar 29 00:00:00 UTC 2021

hnRNPM deficiency leads to cognitive deficits via disrupting synaptic plasticity.

Neuroscience letters

Akinyemi AR,Li D,Zhang J,Liu Q

Fri Apr 23 00:00:00 UTC 2021

Aging-associated lncRNAs are evolutionarily conserved and participate in NFκB signaling.

Nature aging

Cai D,Han JJ

Sat May 01 00:00:00 UTC 2021

Cdh1-APC Regulates Protein Synthesis and Stress Granules in Neurons through an FMRP-Dependent Mechanism.

iScience

Valdez-Sinon AN,Lai A,Shi L,Lancaster CL,Gokhale A,Faundez V,Bassell GJ

Fri May 22 00:00:00 UTC 2020

DIS3L2 Promotes Progression of Hepatocellular Carcinoma via hnRNP U-Mediated Alternative Splicing.

Cancer research

Xing S,Li Z,Ma W,He X,Shen S,Wei H,Li ST,Shu Y,Sun L,Zhong X,Huangfu Y,Su L,Feng J,Zhang X,Gao P,Jia WD,Zhang H

Tue Oct 01 00:00:00 UTC 2019

DIS3L2 Promotes Progression of Hepatocellular Carcinoma via hnRNP U-Mediated Alternative Splicing.

Cancer research

Xing S,Li Z,Ma W,He X,Shen S,Wei H,Li ST,Shu Y,Sun L,Zhong X,Huangfu Y,Su L,Feng J,Zhang X,Gao P,Jia WD,Zhang H

Tue Oct 01 00:00:00 UTC 2019

O-GlcNAcylation of Thr¹²/Ser⁵⁶ in short-form O-GlcNAc transferase (sOGT) regulates its substrate selectivity.

The Journal of biological chemistry

Liu L,Li L,Ma C,Shi Y,Liu C,Xiao Z,Zhang Y,Tian F,Gao Y,Zhang J,Ying W,Wang PG,Zhang L

Fri Nov 08 00:00:00 UTC 2019

Myosin VI in the nucleus of neurosecretory PC12 cells: Stimulation-dependent nuclear translocation and interaction with nuclear proteins.

Nucleus (Austin, Tex.)

Majewski L,Nowak J,Sobczak M,Karatsai O,Havrylov S,Lenartowski R,Suszek M,Lenartowska M,Redowicz MJ

Mon Jan 01 00:00:00 UTC 2018

Myosin VI in the nucleus of neurosecretory PC12 cells: Stimulation-dependent nuclear translocation and interaction with nuclear proteins.

Nucleus (Austin, Tex.)

Majewski L,Nowak J,Sobczak M,Karatsai O,Havrylov S,Lenartowski R,Suszek M,Lenartowska M,Redowicz MJ

Mon Jan 01 00:00:00 UTC 2018

Myosin VI in the nucleus of neurosecretory PC12 cells: Stimulation-dependent nuclear translocation and interaction with nuclear proteins.

Nucleus (Austin, Tex.)

Majewski L,Nowak J,Sobczak M,Karatsai O,Havrylov S,Lenartowski R,Suszek M,Lenartowska M,Redowicz MJ

Mon Jan 01 00:00:00 UTC 2018

Myosin VI in the nucleus of neurosecretory PC12 cells: Stimulation-dependent nuclear translocation and interaction with nuclear proteins.

Nucleus (Austin, Tex.)

Majewski L,Nowak J,Sobczak M,Karatsai O,Havrylov S,Lenartowski R,Suszek M,Lenartowska M,Redowicz MJ

Mon Jan 01 00:00:00 UTC 2018

Identification of novel PANDAR protein interaction partners involved in splicing regulation.

Scientific reports

Pospiech N,Cibis H,Dietrich L,Müller F,Bange T,Hennig S

Mon Feb 12 00:00:00 UTC 2018

Identification of novel PANDAR protein interaction partners involved in splicing regulation.

Scientific reports

Pospiech N,Cibis H,Dietrich L,Müller F,Bange T,Hennig S

Mon Feb 12 00:00:00 UTC 2018

Nuclear TDP-43 causes neuronal toxicity by escaping from the inhibitory regulation by hnRNPs.

Human molecular genetics

Suzuki H,Shibagaki Y,Hattori S,Matsuoka M

Sun Mar 15 00:00:00 UTC 2015

Nuclear TDP-43 causes neuronal toxicity by escaping from the inhibitory regulation by hnRNPs.

Human molecular genetics

Suzuki H,Shibagaki Y,Hattori S,Matsuoka M

Sun Mar 15 00:00:00 UTC 2015

Bioinformatics

Protein Aliases: FLJ30202; FLJ37978; GRIP120; Heterogeneous nuclear ribonucleoprotein U; heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A); heterogenous nuclear ribonucleoprotein U; hnRNP U; HNRNPU antisense RNA 1; NCRNA00201; nuclear matrix protein sp120; Nuclear p120 ribonucleoprotein; p120; p120 nuclear protein; pp120; SAF-A; scaffold attachment factor A; Scaffold-attachment factor A; SP120; system N1 Na+ and H+-coupled glutamine transporter; transporter protein; transporter protein; system N1 Na+ and H+-coupled glutamine transporter; U211

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Gene Aliases: AA408410; AI256620; AL024194; AL024437; AW557595; C1orf199; C86794; hnRNP U; HNRNPU; HNRNPU-AS1; HNRPU; rCG_20317; SAF-A; SAFA; SN1; Sp120; U21.1

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UniProt ID: (Human) Q00839, (Rat) Q6IMY8, (Mouse) Q8VEK3

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Entrez Gene ID: (Human) 3192, (Rat) 117280, (Mouse) 51810

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Function(s)

core promoter binding DNA binding RNA binding protein binding ATP binding poly(G) binding enhancer binding ribonucleoprotein complex binding poly(A) RNA binding telomerase RNA binding transporter activity nucleotide binding

Process(es)

mRNA splicing, via spliceosome osteoblast differentiation RNA processing gene expression positive regulation of gene expression negative regulation of telomere maintenance via telomerase circadian regulation of gene expression CRD-mediated mRNA stabilization cellular response to dexamethasone stimulus positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity transport mRNA processing RNA splicing rhythmic process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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HNRNPU Polyclonal Antibody

HNRNPU Antibody (14599-1-AP) in ICC/IF

Product Details

14599-1-AP

Western Blot (WB)

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

RNA Immunoprecipitation (RIP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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