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Antibody detects endogenous levels of total HOOK1.
This gene encodes a member of the hook family of coiled-coil proteins, which bind to microtubules and organelles through their N- and C-terminal domains, respectively. The encoded protein localizes to discrete punctuate subcellular structures, and interacts with several members of the Rab GTPase family involved in endocytosis. It is thought to link endocytic membrane trafficking to the microtubule cytoskeleton. Several alternatively spliced transcript variants have been identified, but the full-length nature of some of these variants has not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: abnormal spermatozoon head shape; h-hook1; hHK1; hook homolog 1; mHK1; Protein Hook homolog 1
Gene Aliases: A930033L17Rik; azh; HK1; HOOK1
UniProt ID: (Human) Q9UJC3, (Mouse) Q8BIL5
Entrez Gene ID: (Human) 51361, (Mouse) 77963
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