Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Abnova
HOP Polyclonal Antibody, MaxPab™
Promotion
View available promotion(s)
Promo code: {{promo.promoCode}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
FIGURE: 1 / 1
HOP Antibody (H00084525-B01P) in WB
Western Blot analysis of HOPX expression in transfected 293T cell line (H00084525-T01) by HOPX MaxPab polyclonal antibody.
Lane1:HOP transfected lysate(8.14 KDa).
Lane 2:Non-transfected lysate.
Lane1:HOP transfected lysate(8.14 KDa).
Lane 2:Non-transfected lysate.
Product Details
H00084525-B01P
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
HOP (AAH14225, 1 a.a. approximately 73 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
See Label
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: MSAETASGPT EDQVEILEYN FNKVDKHPDS TTLCLIAAEA GLSEEETQKW FKQRLAKWRR SEGLPSECRS VID
Target Information
HOPX is an atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. HOPX acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. HOPX prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. HOPX overexpression causes cardiac hypertrophy and may act as a tumor suppressor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: Homeodomain-only protein; Lung cancer-associated Y protein; not expressed in choriocarcinoma clone 1; Not expressed in choriocarcinoma protein 1; Odd homeobox protein 1
Gene Aliases: CAMEO; HOD; HOP; HOPX; LAGY; NECC1; OB1; SMAP31; TOTO
UniProt ID: (Human) Q9BPY8
Entrez Gene ID: (Human) 84525
negative regulation of transcription from RNA polymerase II promoter
trophectodermal cell differentiation
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
heart development
regulation of heart contraction
histone deacetylation
regulation of protein binding
positive regulation of skeletal muscle tissue regeneration
negative regulation of cell differentiation
lung alveolus development
positive regulation of striated muscle cell differentiation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support