Proteintech

HOPX Polyclonal Antibody

HOPX Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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HOPX Antibody (11419-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human skin cancer tissue slide using 11419-1-AP ( HOPX Antibody) at dilution of 1:200 (under 40x lens). heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

HOPX Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

11419-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 7 publications 7 publications

Immunohistochemistry (IHC)

View 7 publications 7 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

View 10 publications 10 publications

Immunoprecipitation (IP)

0.5-4.0 µg

Miscellaneous PubMed (MISC)

View 1 publication 1 publication

Not applicable (N/A)

View 3 publications 3 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

HOPX Fusion Protein Ag1979 (1-73 aa encoded by BC014225)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.26 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MSAETASGP TEDQVEILEY NFNKVDKHPD STTLCLIAAE AGLSEEETQK WFKQRLAKWR RSEGLPSECR SVID (1-73 aa encoded by BC014225)

Target Information

HOPX is an atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. HOPX acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. HOPX prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. HOPX overexpression causes cardiac hypertrophy and may act as a tumor suppressor.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

HOPX is a tumor-suppressive biomarker that corresponds to T cell infiltration in skin cutaneous melanoma.

Cancer cell international

He S,Ding Y,Ji Z,Yuan B,Chen J,Ren W

Wed Jun 21 00:00:00 UTC 2023

The transcriptional co-activator Yap1 promotes adult hippocampal neural stem cell activation.

The EMBO journal

Fan W,Jurado-Arjona J,Alanis-Lobato G,Péron S,Berger C,Andrade-Navarro MA,Falk S,Berninger B

Thu Jun 01 00:00:00 UTC 2023

Bacterial TLR2/6 Ligands Block Ciliogenesis, Derepress Hedgehog Signaling, and Expand the Neocortex.

mBio

Mann B,Crawford JC,Reddy K,Lott J,Youn YH,Gao G,Guy C,Chou CH,Darnell D,Trivedi S,Bomme P,Loughran AJ,Thomas PG,Han YG,Tuomanen EI

Tue Jun 27 00:00:00 UTC 2023

RAGE inhibition alleviates lipopolysaccharides-induced lung injury via directly suppressing autophagic apoptosis of type II alveolar epithelial cells.

Respiratory research

Xiong X,Dou J,Shi J,Ren Y,Wang C,Zhang Y,Cui Y

Tue Jan 24 00:00:00 UTC 2023

Human alveolar progenitors generate dual lineage bronchioalveolar organoids.

Communications biology

Hoffmann K,Obermayer B,Hönzke K,Fatykhova D,Demir Z,Löwa A,Alves LGT,Wyler E,Lopez-Rodriguez E,Mieth M,Baumgardt M,Hoppe J,Firsching TC,Tönnies M,Bauer TT,Eggeling S,Tran HL,Schneider P,Neudecker J,Rückert JC,Gruber AD,Ochs M,Landthaler M,Beule D,Suttorp N,Hippenstiel S,Hocke AC,Kessler M

Thu Aug 25 00:00:00 UTC 2022

The cortical hem lacks stem cell potential despite expressing SOX9 and HOPX.

Developmental neurobiology

Caramello A,Galichet C,Sopena ML,Lovell-Badge R,Rizzoti K

Sat Oct 01 00:00:00 UTC 2022

Developmental Origins of Human Cortical Oligodendrocytes and Astrocytes.

Neuroscience bulletin

Yang L,Li Z,Liu G,Li X,Yang Z

Sat Jan 01 00:00:00 UTC 2022

The human FOXM1 homolog promotes basal progenitor cell proliferation and cortical folding in mouse.

EMBO reports

Wang W,Su L,Ji F,Zhang D,Wang Y,Zhao J,Jiao RD,Zhang M,Huang E,Jiang H,Zhang J,Jiao J

Thu Feb 03 00:00:00 UTC 2022

Integrated Strategies of Diverse Feature Selection Methods Identify Aging-Based Reliable Gene Signatures for Ischemic Cardiomyopathy.

Frontiers in molecular biosciences

Song H,Chen S,Zhang T,Huang X,Zhang Q,Li C,Chen C,Chen S,Liu D,Wang J,Tu Y,Wu Y,Liu Y

Sat Mar 19 00:00:00 UTC 2022

Single-cell atlas of early human brain development highlights heterogeneity of human neuroepithelial cells and early radial glia.

Nature neuroscience

Eze UC,Bhaduri A,Haeussler M,Nowakowski TJ,Kriegstein AR

Thu Apr 01 00:00:00 UTC 2021

HOPX Plays a Critical Role in Antiretroviral Drugs Induced Epigenetic Modification and Cardiac Hypertrophy.

Cells

Kashyap S,Rabbani M,de Lima I,Kondrachuk O,Patel R,Shafiei MS,Mukker A,Rajakumar A,Gupta MK

Wed Dec 08 00:00:00 UTC 2021

Single-cell analysis of the ventricular-subventricular zone reveals signatures of dorsal and ventral adult neurogenesis.

eLife

Cebrian-Silla A,Nascimento MA,Redmond SA,Mansky B,Wu D,Obernier K,Romero Rodriguez R,Gonzalez-Granero S,García-Verdugo JM,Lim DA,Álvarez-Buylla A

Wed Jul 14 00:00:00 UTC 2021

Single-cell analysis of the ventricular-subventricular zone reveals signatures of dorsal and ventral adult neurogenesis.

eLife

Cebrian-Silla A,Nascimento MA,Redmond SA,Mansky B,Wu D,Obernier K,Romero Rodriguez R,Gonzalez-Granero S,García-Verdugo JM,Lim DA,Álvarez-Buylla A

Wed Jul 14 00:00:00 UTC 2021

RGC-32 Acts as a Hub to Regulate the Transcriptomic Changes Associated With Astrocyte Development and Reactive Astrocytosis.

Frontiers in immunology

Tatomir A,Beltrand A,Nguyen V,Courneya JP,Boodhoo D,Cudrici C,Muresanu DF,Rus V,Badea TC,Rus H

Mon Dec 20 00:00:00 UTC 2021

Tropism of SARS-CoV-2 for Developing Human Cortical Astrocytes.

bioRxiv : the preprint server for biology

Andrews MG,Mukhtar T,Eze UC,Simoneau CR,Perez Y,Mostajo-Radji MA,Wang S,Velmeshev D,Salma J,Kumar GR,Pollen AA,Crouch EE,Ott M,Kriegstein AR

Mon Jan 18 00:00:00 UTC 2021

Cell stress in cortical organoids impairs molecular subtype specification.

Nature

Bhaduri A,Andrews MG,Mancia Leon W,Jung D,Shin D,Allen D,Jung D,Schmunk G,Haeussler M,Salma J,Pollen AA,Nowakowski TJ,Kriegstein AR

Sat Feb 01 00:00:00 UTC 2020

Origins and Proliferative States of Human Oligodendrocyte Precursor Cells.

Cell

Huang W,Bhaduri A,Velmeshev D,Wang S,Wang L,Rottkamp CA,Alvarez-Buylla A,Rowitch DH,Kriegstein AR

Thu Aug 06 00:00:00 UTC 2020

Epigenomic State Transitions Characterize Tumor Progression in Mouse Lung Adenocarcinoma.

Cancer cell

LaFave LM,Kartha VK,Ma S,Meli K,Del Priore I,Lareau C,Naranjo S,Westcott PMK,Duarte FM,Sankar V,Chiang Z,Brack A,Law T,Hauck H,Okimoto A,Regev A,Buenrostro JD,Jacks T

Mon Aug 10 00:00:00 UTC 2020

Assessment of radial glia in the frontal lobe of fetuses with Down syndrome.

Acta neuropathologica communications

Baburamani AA,Vontell RT,Uus A,Pietsch M,Patkee PA,Wyatt-Ashmead J,Chin-Smith EC,Supramaniam VG,Donald Tournier J,Deprez M,Rutherford MA

Thu Aug 20 00:00:00 UTC 2020

mTOR signaling regulates the morphology and migration of outer radial glia in developing human cortex.

eLife

Andrews MG,Subramanian L,Kriegstein AR

Wed Sep 02 00:00:00 UTC 2020

YAP1/TAZ drives ependymoma-like tumour formation in mice.

Nature communications