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Product Details
H00150280-B01P
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
HORMAD2 (NP_689723.1, 1 a.a. approximately 307 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
0.5-1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MATAQLSHCI TIHKASKETV FPSQITNEHE SLKMVKKLFA TSISCITYLR GLFPESSYGE RHLDDLSLKI LREDKKCPGS LHIIRWIQGC FDALEKRYLR MAVLTLYTDP MGSEKVTEMY QFKFKYTKEG ATMDFDSHSS STSFESGTNN EDIKKASVLL IRKLYILMQD LEPLPNNVVL TMKLHYYNAV TPHDYQPLGF KEGVNSHFLL FDKEPINVQV GFVSTGFHSM KVKVMTEATK VIDLENNLFR ENSTTEIAHQ GLDCDEEEEC NDHIQRMNFV CSQQSSECSR KKRKVSEPVK VFIPNRK
Target Information
Essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes. Required for the DNA double-strand break-independent, BRCA1-dependent activation of ATR on the sex chromosomes that is essential for normal sex body formation. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: HORMA domain-containing protein 2
Gene Aliases: CT46.2; HORMAD2
UniProt ID: (Human) Q8N7B1
Entrez Gene ID: (Human) 150280
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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