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Product Details
PA5-51816
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human HORMAD2. Recombinant protein control fragment (Product #RP-91522).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2642518
Product Specific Information
Immunogen sequence: QLSHCITIHK ASKETVFPSQ ITNEHESLKM VKKLFATSIS CITYLRGLFP ESSYGERHLD DLSLKILRED KKCPGSLHII RWIQGCFDAL EKRYLRMAVL TLYTDPMGSE KVTEMYQFKF KYTK
Highest antigen sequence identity to the following orthologs: Mouse - 82%, Rat - 85%.
Target Information
Essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes. Required for the DNA double-strand break-independent, BRCA1-dependent activation of ATR on the sex chromosomes that is essential for normal sex body formation. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: HORMA domain-containing protein 2
Gene Aliases: CT46.2; HORMAD2
UniProt ID: (Human) Q8N7B1
Entrez Gene ID: (Human) 150280
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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