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Abnova
HOXA11 Polyclonal Antibody, MaxPab™
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FIGURE: 1 / 2
HOXA11 Antibody (H00003207-D01P) in WB
Western Blot analysis of HOXA11 expression in transfected 293T cell line (H00003207-T01) by HOXA11 MaxPab polyclonal antibody.
Lane 1: HOXA11 transfected lysate(34.50 KDa).
Lane 2: Non-transfected lysate.
Lane 1: HOXA11 transfected lysate(34.50 KDa).
Lane 2: Non-transfected lysate.
Product Details
H00003207-D01P
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
HOXA11 (NP_005514.1, 1 a.a. approximately 313 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
See Label
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: MDFDERGPCS SNMYLPSCTY YVSGPDFSSL PSFLPQTPSS RPMTYSYSSN LPQVQPVREV TFREYAIEPA TKWHPRGNLA HCYSAEELVH RDCLQAPSAA GVPGDVLAKS SANVYHHPTP AVSSNFYSTV GRNGVLPQAF DQFFETAYGT PENLASSDYP GDKSAEKGPP AATATSAAAA AAATGAPATS SSDSGGGGGC RETAAAAEEK ERRRRPESSS SPESSSGHTE DKAGGSSGQR TRKKRCPYTK YQIRELEREF FFSVYINKEK RLQLSRMLNL TDRQVKIWFQ NRRMKEKKIN RDRLQYYSAN PLL
Target Information
HOX11, also called homeobox11 or Tcl-3 is located at the 10q24 T-Cell translocation breakpoint region. It encodes a homeobox-domain containing protein, HOX11, containing a glycine and proline-rich amino terminus. HOX11 is required for maintenance of the developing spleen and cell survival. The HOX11protein binds to a specific DNA sequence and localizes to the cell nucleus. It transactivates transcription of a reporter gene linked to a cis-regulatory element, acting as a positive transcription activator. The HOX11 gene is highly expressed in T-ALLs as a result of a t (7:10) (q35;q24) or t (10:14) (q24;qll) translocation. The homeobox gene is deregulated upon translocation into the T-cell receptor locus and activates a specific subset of tumor-associated target genes. HOX 11 gene translocation has been attributed to T-cell leukemia and lymphoid neoplasias.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: homeo box 1I; Homeobox protein Hox-1I; Homeobox protein Hox-A11; homeobox protein HOXA11; HOX11
Gene Aliases: HOX1; HOX1I; HOXA11; RUSAT1
UniProt ID: (Human) P31270
Entrez Gene ID: (Human) 3207
skeletal system development
metanephros development
branching involved in ureteric bud morphogenesis
organ induction
transcription, DNA-templated
multicellular organism development
spermatogenesis
single fertilization
mesodermal cell fate specification
male gonad development
anatomical structure morphogenesis
anterior/posterior pattern specification
dorsal/ventral pattern formation
proximal/distal pattern formation
positive regulation of cell development
embryonic limb morphogenesis
positive regulation of chondrocyte differentiation
embryonic forelimb morphogenesis
embryonic digit morphogenesis
positive regulation of transcription, DNA-templated
developmental growth
uterus development
embryonic skeletal joint morphogenesis
cartilage development involved in endochondral bone morphogenesis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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