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Invitrogen
HOXB4 Monoclonal Antibody (3A2F2)
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Product Details
MA5-31768
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
3A2F2
Immunogen
Purified recombinant fragment of human HOXB4 (AA: 16-251) expressed in E. coli.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein G
Storage buffer
PBS
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2787391
Product Specific Information
MA5-31768 has been tested in indirect ELISA.
Target Information
HOX homeobox genes play a role both in the early stem cell function as well as in later stages of hematopoietic differentiation. HOXB4, specifically, is a homeotic selector gene implicated in self-renewal of definitive HSCs. Expression of HOXB4 in primitive progenitors combined with culture on hematopoietic stroma induced a switch to the definitive HSC phenotype. Activation of WNT signaling in HSCs induced increased expression of HOXB4. Perturbations of HOX gene expression can cause leukemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: homeo box 2F; homeo box B4; Homeobox protein Hox-2.6; Homeobox protein Hox-2F; Homeobox protein Hox-B4
Gene Aliases: HOX-2.6; HOX2; HOX2F; HOXB4
UniProt ID: (Human) P17483
Entrez Gene ID: (Human) 3214
negative regulation of transcription from RNA polymerase II promoter
morphogenesis of an epithelial sheet
transcription, DNA-templated
cell proliferation
anterior/posterior pattern specification
positive regulation of transcription from RNA polymerase II promoter
somatic stem cell division
spleen development
bone marrow development
embryonic skeletal system morphogenesis
definitive hemopoiesis
hematopoietic stem cell differentiation
positive regulation of stem cell differentiation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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