Invitrogen

HOXB7 Polyclonal Antibody

FIGURE: 1 / 11

HOXB7 Antibody (40-2000) in WB

Western Blot analysis of (A) A375, (B) NTERA (NT2/D1), (C) SK-MEL-19, (D) SK-MEL-37, (E) KARPAS 299, (F) SW480, and (G) HT-29 cell lysates using Zymed Rb anti-HOXB7 (Product # 40-2000).

Product Image Gallery

HOXB7 Antibody — Protein expression of HOXB7 following transfection for 72 h: Con-B group, blank control group; Sn group, negative control siRNA; S1 group, S1 transfection group; S2 group, S2 transfection group and S3 group, S3 transfection group. (A) The protein expression level of HOXB7 was measured by western blotting. (B) The optical density for target protein is shown as a proportion of GAPDH optical density. Cells in the S3 group had the lowest HOXB7 protein expression level (***P<0.001, compared with the Con B and Sn groups). HOXB7, homeobox B7. {KD}

Product Details

40-2000

Applications

Tested Dilution

Publications

Western Blot (WB)

Assay-dependent

View 7 publications 7 publications

Immunohistochemistry (IHC)

- -

Immunocytochemistry (ICC/IF)

Assay-dependent

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide derived from the C-terminal region of the human HOXB7 (homeobox B7, homeobox C1) protein

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.25 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.4

Contains

0.1% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

AB_2533454

Target Information

The homeobox genes encode transcription factors that regulate developmental processes such as body patterning and organogenesis. The mammalian HOX gene complex consists of 39 genes that are located on 4 linkage groups (clusters), dispersed over 4 chromosomes (HOXA, HOXB, HOXC and HOXD). HOXB7 is expressed in most malignant T-cell lines and CD4-positive peripheral blood cells, and is constitutively expressed in both melanoma primary lesions and cell lines. HOXB7 binds to and transactivates bFGF in melanoma cell lines but SkBr3 breast adenocarcinoma is negative for the expression of both HOXB7 and bFGF genes. HOXB7 may be a key activator of tumor-associated neoangiogenesis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Mitogen-activated protein kinase inhibition augments the T cell response against HOXB7-expressing tumor through human leukocyte antigen upregulation.

Cancer science

Komatsuda H,Wakisaka R,Kono M,Kumai T,Hayashi R,Yamaki H,Sato R,Nagato T,Ohkuri T,Kosaka A,Ohara K,Takahara M,Katada A,Kobayashi H

Published figure using HOXB7 polyclonal antibody (Product # 40-2000) in Western Blot

Wed Feb 01 00:00:00 UTC 2023

Silencing of hsa_circ_0009035 Suppresses Cervical Cancer Progression and Enhances Radiosensitivity through MicroRNA 889-3p-Dependent Regulation of HOXB7.

Molecular and cellular biology

Zhao X,Dong W,Luo G,Xie J,Liu J,Yu F

40-2000 was used in Western Blotting to investigate circular RNAs and microRNAs influencing HoXB7 in cervical cancer.

Fri May 21 00:00:00 UTC 2021

Silencing of hsa_circ_0009035 Suppresses Cervical Cancer Progression and Enhances Radiosensitivity through MicroRNA 889-3p-Dependent Regulation of HOXB7.

Molecular and cellular biology

Zhao X,Dong W,Luo G,Xie J,Liu J,Yu F

40-2000 was used in Western Blotting to investigate circular RNAs and microRNAs influencing HoXB7 in cervical cancer.

Fri May 21 00:00:00 UTC 2021

Long non-coding RNA SNHG8 promotes prostate cancer progression through repressing miR-384 and up-regulating HOXB7.

The journal of gene medicine

Shi Z,Zhang H,Jie S,Yang X,Huang Q,Mao Y,Zhang Y

40-2000 was used in Western Blotting to probe the function of lncRNA small nucleolar RNA host gene 8 (SNHG8) in prostate cancer progression.

Mon Mar 01 00:00:00 UTC 2021

Long non-coding RNA SNHG8 promotes prostate cancer progression through repressing miR-384 and up-regulating HOXB7.

The journal of gene medicine

Shi Z,Zhang H,Jie S,Yang X,Huang Q,Mao Y,Zhang Y

40-2000 was used in Western Blotting to probe the function of lncRNA small nucleolar RNA host gene 8 (SNHG8) in prostate cancer progression.

Mon Mar 01 00:00:00 UTC 2021

Psoralen Suppresses Cisplatin-Mediated Resistance and Induces Apoptosis of Gastric Adenocarcinoma by Disruption of the miR196a-HOXB7-HER2 Axis.

Cancer management and research

Jin L,Ma XM,Wang TT,Yang Y,Zhang N,Zeng N,Bai ZG,Yin J,Zhang J,Ding GQ,Zhang ZT

40-2000 was used in Western Blotting to investigate the impact of psoralen on miR-196a-5p expression and function, and to reveal the mechanism underlying miR-196a-5p-mediated inhibition and the reversal of cisplatin resistance.

Thu Apr 14 00:00:00 UTC 2022

Psoralen Suppresses Cisplatin-Mediated Resistance and Induces Apoptosis of Gastric Adenocarcinoma by Disruption of the miR196a-HOXB7-HER2 Axis.

Cancer management and research

Jin L,Ma XM,Wang TT,Yang Y,Zhang N,Zeng N,Bai ZG,Yin J,Zhang J,Ding GQ,Zhang ZT

Thu Apr 14 00:00:00 UTC 2022

Targeting HOX/PBX dimer formation as a potential therapeutic option in esophageal squamous cell carcinoma.

Cancer science

Shen LY,Zhou T,Du YB,Shi Q,Chen KN

40-2000 was used in Immunocytochemistry-immunoflourescence to explore whether oesophageal squamous cell carcinoma cells are sensitive to HXR9 disrupting the interaction between multiple HOX proteins and their cofactor PBX.

Wed May 01 00:00:00 UTC 2019

The roles of HOXB7 in promoting migration, invasion, and anti-apoptosis in gastric cancer.

Journal of gastroenterology and hepatology

Joo MK,Park JJ,Yoo HS,Lee BJ,Chun HJ,Lee SW,Bak YT

40-2000 was used in western blot to study promotion of invasion, migration and anti-apoptosis in gastric cancer and the role of HOXB7

Sat Oct 01 00:00:00 UTC 2016

HOXB7-S3 inhibits the proliferation and invasion of MCF-7 human breast cancer cells.

Molecular medicine reports

Ma R,Zhang D,Hu PC,Li Q,Lin CY

40-2000 was used in western blot to determine the effects of HOXB7 on the proliferation and invasion of breast cancer cells.

Thu Oct 01 00:00:00 UTC 2015

HOXB7 expression by myeloma cells regulates their pro-angiogenic properties in multiple myeloma patients.

Leukemia

Storti P,Donofrio G,Colla S,Airoldi I,Bolzoni M,Agnelli L,Abeltino M,Todoerti K,Lazzaretti M,Mancini C,Ribatti D,Bonomini S,Franceschi V,Pistoia V,Lisignoli G,Pedrazzini A,Cavicchi O,Neri A,Rizzoli V,Giuliani N

Tue Mar 01 00:00:00 UTC 2011

Bioinformatics

Protein Aliases: homeo box 2C; homeo box B7; homeo box c1 protein; Homeobox protein HHO.C1; Homeobox protein Hox-2C; Homeobox protein Hox-B7; Hox-23

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Gene Aliases: HHO.C1; Hox-2.3; HOX2; HOX2C; HOXB7

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UniProt ID: (Human) P09629

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Entrez Gene ID: (Human) 3217

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Function(s)

transcription factor activity, sequence-specific DNA binding protein binding sequence-specific DNA binding

Process(es)

transcription, DNA-templated regulation of transcription, DNA-templated multicellular organism development anterior/posterior pattern specification myeloid cell differentiation embryonic skeletal system morphogenesis positive regulation of branching involved in ureteric bud morphogenesis

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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HOXB7 Polyclonal Antibody

HOXB7 Antibody (40-2000) in WB

Product Details

40-2000

Western Blot (WB)

Immunohistochemistry (IHC)

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID

Target Information

Bioinformatics

Performance Guarantee

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