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Invitrogen
HOXB8 Polyclonal Antibody
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Product Details
PA5-41172
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide directed towards the middle region of human HOXB8
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2609323
Product Specific Information
Peptide sequence: FQNRRMKWKK ENNKDKFPSS KCEQEELEKQ KLERAPEAAD EGDAQKGDKK
Sequence homology: Dog: 100%; Human: 100%; Mouse: 79%; Pig: 100%; Rat: 79%
Target Information
This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with colorectal cancer. Mice that have had the murine ortholog of this gene knocked out exhibit an excessive pathologic grooming behavior. This behavior is similar to the behavior of humans suffering from the obsessive-compulsive spectrum disorder trichotillomania.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: homeo box 2D; homeo box B8; Homeobox protein Hox-2.4; Homeobox protein Hox-2D; Homeobox protein Hox-B8
Gene Aliases: Hox-2.4; HOX2; HOX2D; HOXB8
UniProt ID: (Human) P17481
Entrez Gene ID: (Human) 3218
transcription, DNA-templated
regulation of transcription, DNA-templated
grooming behavior
adult locomotory behavior
anterior/posterior pattern specification
sensory perception of pain
dorsal spinal cord development
negative regulation of myeloid cell differentiation
embryonic skeletal system morphogenesis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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