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OriGene
HOXD8 Monoclonal Antibody (OTI3C4), TrueMAB™
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Product Details
CF810958
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI3C4
Immunogen
Human recombinant protein fragment corresponding to amino acids 69-290 of human HOXD8 (NP_062458) produced in E.coli.
Conjugate
Form
Lyophilized
Concentration
See Label
Purification
Protein A/G
Storage buffer
PBS, pH 7.3, with 8% trehalose
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. In addition to effects during embryogenesis, this particular gene may also play a role in adult urogenital tract function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: homeo box 4E; homeo box D8; homeobox protein 5.4; Homeobox protein Hox-4.3; Homeobox protein Hox-4E; Homeobox protein Hox-5.4; Homeobox protein Hox-D8; Hox-4.5
Gene Aliases: 4921540P06Rik; AI047735; Hox-4.3; Hox-5.4; HOX4; HOX4E; HOX5.4; Hoxd-8; HOXD8
UniProt ID: (Human) P13378, (Mouse) P23463
Entrez Gene ID: (Human) 3234, (Mouse) 15437
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
multicellular organism development
anterior/posterior pattern specification
positive regulation of transcription from RNA polymerase II promoter
skeletal system morphogenesis
anterior/posterior axis specification, embryo
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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