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HPS1 Polyclonal Antibody

HPS1 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 9

HPS1 Antibody (15077-1-AP) in ICC/IF

Immunofluorescent analysis of ( -20°C Ethanol ) fixed L02 cells using 15077-1-AP (HPS1 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

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Product Details

15077-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:300-1:800

View 2 publications 2 publications

Immunocytochemistry (ICC/IF)

1:50-1:500

View 1 publication 1 publication

RNA Immunoprecipitation (RIP)

View 1 publication 1 publication

Miscellaneous PubMed (MISC)

View 1 publication 1 publication

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

HPS1 Fusion Protein Ag7149 (1-324 aa encoded by BC000175)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.24 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MKCVLVATE GAEVLFYWTD QEFEESLRLK FGQSENEEEE LPALEDQLST LLAPVIISSM TMLEKLSDTY TCFSTENGNF LYVLHLFGEC LFIAINGDHT ESEGDLRRKL YVLKYLFEVH FGLVTVDGHL IRKELRPPDL AQRVQLWEHF QSLLWTYSRL REQEQCFAVE ALERLIHPQL CELCIEALER HVIQAVNTSP ERGGEEALHA FLLVHSKLLA FYSSHSASSL RPADLLALIL LVQDLYPSES TAEDDIQPSP RRARSSQNIP VQQAWSPHST GPTGGSSAET ETDSFSLPEE YFTPAPSPGD QSSGEDRRKA GGNNS (1-324 aa encoded by BC000175)

Target Information

Hermansky-Pudlak syndrome (HPS) is a rare, genetically heterogeneous, autosomal recessive disorder. It is characterized by oculocutaneous albinism, lysosomal storage defects and prolonged bleeding due to platelet storage pool deficiency. There are 10 HPS genes encoding HPS proteins that all interact within three distinct ubiquitously expressed protein complexes or biogenesis of lysosome-related organelle complexes. Defects in these genes cause HPS. HSP-1 is a component of multiple cytoplasmic organelles and is important for their normal development and function. It plays a role in intracellular protein sorting.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Long non-coding RNA NRSN2-AS1, transcribed by SOX2, promotes progression of esophageal squamous cell carcinoma by regulating the ubiquitin-degradation of PGK1.

Clinical & experimental metastasis

Xu T,Yan Z,Lu J,Chen L,Li X,Li Y,Dong Z,Guo W

Sat Oct 01 00:00:00 UTC 2022

Gene-edited MLE-15 Cells as a Model for the Hermansky-Pudlak Syndromes.

American journal of respiratory cell and molecular biology

Kook S,Qi A,Wang P,Meng S,Gulleman P,Young LR,Guttentag SH

Tue May 01 00:00:00 UTC 2018

Gene-edited MLE-15 Cells as a Model for the Hermansky-Pudlak Syndromes.

American journal of respiratory cell and molecular biology

Kook S,Qi A,Wang P,Meng S,Gulleman P,Young LR,Guttentag SH

Tue May 01 00:00:00 UTC 2018

Gene-edited MLE-15 Cells as a Model for the Hermansky-Pudlak Syndromes.

American journal of respiratory cell and molecular biology

Kook S,Qi A,Wang P,Meng S,Gulleman P,Young LR,Guttentag SH

Tue May 01 00:00:00 UTC 2018

Gene-edited MLE-15 Cells as a Model for the Hermansky-Pudlak Syndromes.

American journal of respiratory cell and molecular biology

Kook S,Qi A,Wang P,Meng S,Gulleman P,Young LR,Guttentag SH

Tue May 01 00:00:00 UTC 2018

In vitro functional correction of Hermansky-Pudlak Syndrome type-1 by lentiviral-mediated gene transfer.

Molecular genetics and metabolism

Ikawa Y,Hess R,Dorward H,Cullinane AR,Huizing M,Gochuico BR,Gahl WA,Candotti F

Thu Jan 01 00:00:00 UTC 2015

In vitro functional correction of Hermansky-Pudlak Syndrome type-1 by lentiviral-mediated gene transfer.

Molecular genetics and metabolism

Ikawa Y,Hess R,Dorward H,Cullinane AR,Huizing M,Gochuico BR,Gahl WA,Candotti F

Thu Jan 01 00:00:00 UTC 2015

Dysregulation of galectin-3. Implications for Hermansky-Pudlak syndrome pulmonary fibrosis.

American journal of respiratory cell and molecular biology

Cullinane AR,Yeager C,Dorward H,Carmona-Rivera C,Wu HP,Moss J,O'Brien KJ,Nathan SD,Meyer KC,Rosas IO,Helip-Wooley A,Huizing M,Gahl WA,Gochuico BR

Sat Mar 01 00:00:00 UTC 2014

Dysregulation of galectin-3. Implications for Hermansky-Pudlak syndrome pulmonary fibrosis.

American journal of respiratory cell and molecular biology

Cullinane AR,Yeager C,Dorward H,Carmona-Rivera C,Wu HP,Moss J,O'Brien KJ,Nathan SD,Meyer KC,Rosas IO,Helip-Wooley A,Huizing M,Gahl WA,Gochuico BR

Sat Mar 01 00:00:00 UTC 2014

Bioinformatics

Protein Aliases: BLOC-3 complex member HPS1; Hermansky-Pudlak syndrome 1 protein; MGC5277

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Gene Aliases: BLOC3S1; HPS; HPS1

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UniProt ID: (Human) Q92902

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Entrez Gene ID: (Human) 3257

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Function(s)

protein binding protein dimerization activity

Process(es)

lysosome organization visual perception response to stimulus

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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HPS1 Polyclonal Antibody

HPS1 Antibody (15077-1-AP) in ICC/IF

Product Details

15077-1-AP

Western Blot (WB)

Immunocytochemistry (ICC/IF)

RNA Immunoprecipitation (RIP)

Miscellaneous PubMed (MISC)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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