OriGene

HRAS Monoclonal Antibody (OTI1A1), TrueMAB™

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Datasheet
Protocols
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Datasheet
Protocols
Questions & Answers

Product Details

TA505676

Applications
Tested Dilution
Publications

Western Blot (WB)

1:200-1:4000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:150
-

Immunocytochemistry (ICC/IF)

1:100
-
Product Specifications

Species Reactivity

Dog, Human, Mouse, Rat

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

OTI1A1

Immunogen

Full length human recombinant protein of human HRAS produced in HEK293T cell.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS with 1% BSA, 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

Monomeric G protein Ras functions as a molecular switch linking receptor and nonreceptor tyrosine kinase activation to a number of downstream signaling pathways leading to distinct cytoplasmic or nuclear events. Each mammalian cell contains three Ras proto-oncogene coding for closely related Ras proteins: H-, K-, N-Ras. Oncogenic mutations in Ras genes are present in ~30% of all human cancers. Constitutive activation of Ras due to mutations or overexpression stimulates proliferation and inhibition of apoptosis. K-Ras mutations are common in pancreatic, colorectal and nonsmall-cell lung carcinomas; H-Ras mutations are common in bladder, kidney and thyroid carcinomas; N-Ras mutations are found in melanoma, hematological malignancies and hepatocellular carcinaoma.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: c-H-ras; c-Ha-ras p21 protein; c-Ha-ras transgene; c-has/bas p21 protein; c-ras-Ki-2 activated oncogene; GTP- and GDP-binding peptide B; GTPase HRas; GTPase Hras1; H-ras 1 protein; H-Ras-1; Ha-Ras; Ha-Ras1 proto-oncoprotein; Harvey ras1 protein; Harvey rat sarcoma viral (v-Ha-ras) oncogene homolog; Harvey rat sarcoma viral oncogene homolog; Harvey rat sarcoma viral oncoprotein; Harvey rat sarcoma virus oncogene 1; p19 H-RasIDX protein; p21ras; Ras family small GTP binding protein H-Ras; ras p21; transformation gene: oncogene HAMSV; Transforming protein p21; v-Ha-ras Harvey rat sarcoma viral oncogene homolog

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Gene Aliases: C-BAS/HAS; C-H-RAS; c-Ha-ras; C-HA-RAS1; c-rasHa; CTLO; H-RAS; H-RASIDX; Ha-ras; HAMSV; Harvey-ras; HRAS; Hras-1; HRAS1; Kras2; p21ras; ras; RASH1

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UniProt ID: (Human) P01112, (Mouse) Q61411, (Rat) P20171

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Entrez Gene ID: (Dog) 403735, (Human) 3265, (Mouse) 15461, (Rat) 293621

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Function(s)
GTPase activity protein binding GTP binding protein C-terminus binding nucleotide binding
Process(es)
positive regulation of protein phosphorylation endocytosis apoptotic process cell cycle arrest mitotic cell cycle checkpoint signal transduction small GTPase mediated signal transduction Ras protein signal transduction cell aging cell proliferation positive regulation of cell proliferation negative regulation of cell proliferation positive regulation of gene expression negative regulation of gene expression positive regulation of cell migration negative regulation of GTPase activity positive regulation of MAP kinase activity positive regulation of MAPK cascade negative regulation of neuron apoptotic process positive regulation of GTPase activity positive regulation of DNA replication positive regulation of transcription from RNA polymerase II promoter positive regulation of JNK cascade positive regulation of Ras protein signal transduction regulation of long-term neuronal synaptic plasticity positive regulation of epithelial cell proliferation protein heterooligomerization positive regulation of ERK1 and ERK2 cascade positive regulation of wound healing cellular senescence intrinsic apoptotic signaling pathway positive regulation of ruffle assembly positive regulation of actin cytoskeleton reorganization positive regulation of miRNA metabolic process visual learning actin cytoskeleton organization regulation of synaptic transmission, GABAergic positive regulation of Rac protein signal transduction social behavior negative regulation of cell differentiation striated muscle cell differentiation epithelial tube branching involved in lung morphogenesis MAPK cascade stimulatory C-type lectin receptor signaling pathway chemotaxis cell surface receptor signaling pathway epidermal growth factor receptor signaling pathway axon guidance organ morphogenesis positive regulation of interferon-gamma production Fc-epsilon receptor signaling pathway ERBB2 signaling pathway T-helper 1 type immune response defense response to protozoan ephrin receptor signaling pathway T cell receptor signaling pathway leukocyte migration
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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