Proteintech

HRC Polyclonal Antibody

HRC Antibody in Immunocytochemistry (ICC/IF)

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HRC Antibody (18142-1-AP) in ICC/IF

Immunofluorescent analysis of ( -20°C Ethanol ) fixed HeLa cells using 18142-1-AP (HRC antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

HRC Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Product Details

18142-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 2 publications 2 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:200

Immunocytochemistry (ICC/IF)

1:50-1:500

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

HRC Fusion Protein Ag12794 (26-350 aa encoded by BC069795)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.35 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MTQQLRGDG LGFRNRNNST GVAGLSEEAS AELRHHLHSP RDHPDENKDV STENGHHFWS HPDREKEDED VSKEYGHLLP GHRSQDHKVG DEGVSGEEVF AEHGGQARGH RGHGSEDTED SAEHRHHLPS HRSHSHQDED EDEVVSSEHH HHILRHGHRG HDGEDDEGEE EEEEEEEEEE ASTEYGHQAH RHRGHGSEED EDVSDGHHHH GPSHRHQGHE EDDDDDDDDD DDDDDDDVSI EYRHQAHRHQ GHGIEEDEDV SDGHHHRDPS HRHRSHEEDD NDDDDVSTEY GHQAHRHQDH RKEEVEAVSG EHHHHVPDHR HQGHRD (26-350 aa encoded by BC069795)

Target Information

May play a role in the regulation of calcium sequestration or release in the SR of skeletal and cardiac muscle.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Single-cell RNA-seq of heart reveals intercellular communication drivers of myocardial fibrosis in diabetic cardiomyopathy.

eLife

Li W,Lou X,Zha Y,Qin Y,Zha J,Hong L,Xie Z,Yang S,Wang C,An J,Zhang Z,Qiao S

Mon Apr 03 00:00:00 UTC 2023

Vitamin D alleviates liver fibrosis by inhibiting histidine-rich calcium binding protein (HRC).

Chemico-biological interactions

Lu W,Li X,Liu N,Zhang Y,Li Y,Pan Y,Yang J,Liu Z,Kong J

Mon Jan 25 00:00:00 UTC 2021

Inhibition of lung cancer by vitamin D depends on downregulation of histidine-rich calcium-binding protein.

Journal of advanced research

Liu N,Li X,Fu Y,Li Y,Lu W,Pan Y,Yang J,Kong J

Mon Mar 01 00:00:00 UTC 2021

Inhibition of lung cancer by vitamin D depends on downregulation of histidine-rich calcium-binding protein.

Journal of advanced research

Liu N,Li X,Fu Y,Li Y,Lu W,Pan Y,Yang J,Kong J

Mon Mar 01 00:00:00 UTC 2021

Bioinformatics

Protein Aliases: Sarcoplasmic reticulum histidine-rich calcium-binding protein

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Gene Aliases: HCP; HRC

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UniProt ID: (Human) P23327

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Entrez Gene ID: (Human) 3270, (Mouse) 15464

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Function(s)

calcium ion binding protein binding ion channel binding ATPase binding

Process(es)

regulation of heart rate muscle contraction positive regulation of heart rate regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion regulation of peptidyl-serine phosphorylation positive regulation of heart contraction regulation of cytosolic calcium ion concentration negative regulation of cytosolic calcium ion concentration regulation of ryanodine-sensitive calcium-release channel activity regulation of cell communication by electrical coupling involved in cardiac conduction positive regulation of relaxation of cardiac muscle regulation of calcium ion transmembrane transport regulation of heart contraction calcium ion homeostasis negative regulation of calcium ion import into sarcoplasmic reticulum

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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HRC Polyclonal Antibody

HRC Antibody (18142-1-AP) in ICC/IF

Product Details

18142-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Species Reactivity

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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