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Proteintech
HRG Polyclonal Antibody
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Product Details
26252-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
HRG Fusion Protein Ag16278 (19-368 aa encoded by BC069574)
Conjugate
Form
Liquid
Concentration
0.36 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: VSPTDCSAV EPEAEKALDL INKRRRDGYL FQLLRIADAH LDRVENTTVY YLVLDVQESD CSVLSRKYWN DCEPPDSRRP SEIVIGQCKV IATRHSHESQ DLRVIDFNCT TSSVSSALAN TKDSPVLIDF FEDTERYRKQ ANKALEKYKE ENDDFASFRV DRIERVARVR GGEGTGYFVD FSVRNCPRHH FPRHPNVFGF CRADLFYDVE ALDLESPKNL VINCEVFDPQ EHENINGVPP HLGHPFHWGG HERSSTTKPP FKPHGSRDHH HPHKPHEHGP PPPPDERDHS HGPPLPQGPP PLLPMSCSSC QHATFGTNGA QRHSHNNNSS DLHPHKHHSH EQHPHGHHPH A (19-368 aa encoded by BC069574)
Target Information
HRG contains two cystatin-like domains and is located in plasma and platelets. The physiological function has not been determined but it is known that the protein binds heme, dyes and divalent metal ions. It can inhibit rosette formation and interacts with heparin, thrombospondin and plasminogen. Two of the protein's effects, the inhibition of fibrinolysis and the reduction of inhibition of coagulation, indicate a potential prothrombotic effect. Mutations in this gene lead to thrombophilia due to abnormal histidine-rich glycoprotein levels.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: DKFZp779H1622; Histidine-proline-rich glycoprotein; Histidine-rich glycoprotein; HPRG
Gene Aliases: HPRG; HRG; HRGP; THPH11
UniProt ID: (Human) P04196
Entrez Gene ID: (Human) 3273
angiogenesis
platelet degranulation
positive regulation of immune response to tumor cell
chemotaxis
negative regulation of cell adhesion
negative regulation of cell proliferation
regulation of gene expression
regulation of platelet activation
negative regulation of lamellipodium assembly
negative regulation of endopeptidase activity
heme transport
negative regulation of angiogenesis
platelet activation
regulation of blood coagulation
negative regulation of cell growth
regulation of actin cytoskeleton organization
negative regulation of cell adhesion mediated by integrin
fibrinolysis
positive regulation of apoptotic process
regulation of protein complex assembly
negative regulation of blood vessel endothelial cell migration
regulation of peptidyl-tyrosine phosphorylation
defense response to fungus
positive regulation of focal adhesion assembly
negative regulation of fibrinolysis
negative regulation of vascular endothelial growth factor signaling pathway
positive regulation of blood vessel remodeling
negative regulation of endothelial cell chemotaxis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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