Invitrogen

HSD3B1 Monoclonal Antibody (FDO66Q)

View all (17) HSD3B1 antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

MA1-46438

Applications
Tested Dilution
Publications

Western Blot (WB)

Assay-Dependent
-

Immunohistochemistry (Paraffin) (IHC (P))

10-20 µg/mL
-

Immunohistochemistry (Frozen) (IHC (F))

10-20 µg/mL
-

Immunocytochemistry (ICC/IF)

10-20 µg/mL
-
Product Specifications

Species Reactivity

Baboon, Bovine, Goat, Human, Mouse, Non-human primate, Sheep, Pig, Rat

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

FDO66Q

Immunogen

JEG Choriocarcinoma cells.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein G

Storage buffer

TBS

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2120102

Product Specific Information

Suggested positive control: human placental villi, antigen standard for HSD3B1 (transient overexpression lysate).

Target Information

Amyloid beta peptide (Abeta/Beta-amyloid) is the major constituent of amyloid plaques in the brains of individuals afflicted with Alzheimer's disease. Abeta peptide is 40-43 amino acids long and generated from the beta-amyloid precursor protein (beta APP) in a two-step process. The first step involves cleavage of the extracellular, amino-terminal domain of beta APP. Protein cleavage is performed by an aspartyl protease, beta-secretase (BACE) which is synthesized as a propeptide and must be modified to the mature and active form by the prohormone convertase, furin. Beta APP cleavage by the mature form of BACE results in the cellular secretion of a segment of beta APP, and a membrane-bound remnant. The remnant protein is processed by another protease, gamma-secretase. Gamma-secretase cleaves an intra-membrane site in the carboxyl-terminal domain of beta APP, thus generating the amyloid beta peptide. Gamma-secretase is believed to be a multi-subunit complex containing presenilin-1 and 2 as central components. The transmembrane glycoprotein, nicastrin, is associated with presinilins and has been found to bind to the carboxyl-terminus of beta APP and helps to modulate the production of the amyloid beta peptide. Abeta is an extracellular filamentous protein component of amyloid cores, neuritic plaques and is also found as a deposit in neurofibrillary tangles. Alzheimer's disease, the most common cause of senile dementia, is characterized by abnormal filamentous protein deposits in the brain. Beta amyloid deposits are also detected in Lewy body dementia, Down's syndrome, amyloidosis (Dutch type), cerebroarterial amyloidosis (cerebral amyloid angiopathy) and in the Guam Parkinson-Dementia complex.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 3 beta-hydroxysteroid dehydrogenase 1; 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase; 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1; 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I; 3-beta-HSD; 3-beta-HSD I; 3-beta-hydroxy-5-ene steroid dehydrogenase; 3-beta-hydroxy-Delta(5)-steroid dehydrogenase; 3-beta-hydroxysteroid 3-dehydrogenase; 3-beta-hydroxysteroid dehydrogenase/delta-5-delta-4 isomerase; 3beta-hydroxysteroid dehydrogenase/isomerase; Delta-5-3-ketosteroid isomerase; Dihydrotestosterone oxidoreductase; HGNC:5217; hydroxy-delta-MAY-steroid dehydrogenase, 3 beta- and steroid delta-isomerase; hydroxysteroid dehydrogenase-1, delta<5>-3-beta; progesterone reductase; short chain dehydrogenase/reductase family 11E, member 1; Steroid Delta-isomerase; Trophoblast antigen FDO161G

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Gene Aliases: 3-beta-HSD I; 3B-HSD; 3BETAHSD; 3BH; 3BHSD; BOS_3048; D3Ertd383e; HSD3B; HSD3B1; HSDB3; HSDB3A; I; SDR11E1

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UniProt ID: (Human) P14060, (Pig) Q9N119, (Bovine) P14893, (Rat) P22071, (Mouse) P24815

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Entrez Gene ID: (Sheep) 100190978, (Human) 3283, (Pig) 445539, (Bovine) 281824, (Rat) 360348, (Mouse) 15492

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Function(s)
3-beta-hydroxy-delta5-steroid dehydrogenase activity steroid delta-isomerase activity steroid binding dihydrotestosterone 17-beta-dehydrogenase activity NAD binding
Process(es)
organic acid metabolic process steroid biosynthetic process progesterone biosynthetic process estrogen biosynthetic process steroid metabolic process C21-steroid hormone metabolic process male gonad development female gonad development response to herbicide response to organic substance response to metal ion response to lithium ion response to lead ion response to organic cyclic compound response to activity diterpenoid metabolic process insecticide metabolic process biphenyl metabolic process dibenzo-p-dioxin metabolic process phenol-containing compound metabolic process toluene metabolic process hippocampus development adrenal gland development ovulation granulocyte differentiation response to nutrient levels response to estradiol cellular response to insulin stimulus response to vitamin E Leydig cell differentiation response to L-ascorbic acid response to drug response to alkaloid cellular response to fibroblast growth factor stimulus response to ethanol phosphatidylcholine metabolic process response to arsenic-containing substance response to cadmium ion response to corticosterone response to calcium ion oxidation-reduction process maternal process involved in female pregnancy response to fungicide testosterone biosynthetic process cellular response to hydrogen peroxide response to fatty acid cellular response to antibiotic cellular response to mercury ion cellular response to cAMP cellular response to glucose stimulus cellular response to gonadotropin stimulus cellular response to follicle-stimulating hormone stimulus cellular response to luteinizing hormone stimulus cellular response to methylmercury cellular response to dexamethasone stimulus cellular response to transforming growth factor beta stimulus androgen biosynthetic process glucocorticoid biosynthetic process mineralocorticoid biosynthetic process
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