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Invitrogen
HSP104 Polyclonal Antibody
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Product Details
PA3-016A
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Yeast
Published species
Yeast
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to C-terminal residues D(894) D D N E D S M E I D D D L D(908) of S. cerevisiae HSP104.
Conjugate
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
whole serum
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_1017672
Product Specific Information
PA3-016A detects HSP104 from yeast samples. This antibody does not detect HSP100 from prokaryotes, nor certain plants and insects including Drosophila.
PA3-016A has been successfully used in Western blot procedures. By Western blot, this antibody detects a single ~104 kDa protein from yeast.
The PA3-016A immunogen is a synthetic peptide corresponding to the C-terminal residues D(894) D D N E D S M E I D D D L D(908) of S. cerevisiae HSP104.
Target Information
Heat shock proteins (HSP) are expressed in response to various biological stresses, including high temperatures. There are several major families of HSPs including HSP70, HSP90 and HSP100. The HSP100 proteins generally have amino acid sequences of about 900 residues and contain two nucleotide-binding sites. Within the HSP100 family of proteins, yeast express an ~104 kDa form which is necessary to protect cells from various stress conditions such as heat, heavy metals and ethanol, though mutation studies have shown that the protein is not required for normal growth. Yeast HSP104 has been shown to be a ClpB protein with significant sequence homology to E. coli ClpB, particularly in the two nucleotide-binding sites.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: chaperone ATPase HSP104; Heat shock protein; Heat shock protein 104; HS104; HSP; Protein aggregation-remodeling factor HSP104
Gene Aliases: HSP104; L0948; YLL026W
UniProt ID: (Baker's yeast) P31539
Entrez Gene ID: (Baker's yeast) 850633
inheritance of oxidatively modified proteins involved in replicative cell aging
response to stress
protein metabolic process
protein folding in endoplasmic reticulum
protein unfolding
cellular heat acclimation
chaperone cofactor-dependent protein refolding
trehalose metabolism in response to heat stress
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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