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HSPA1B Monoclonal Antibody (2D11)

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

H00003304-M05

Applications
Tested Dilution
Publications

Western Blot (WB)

1-5 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

3 µg/mL
-

ELISA (ELISA)

0.03 ng/mL
-

in situ PLA (PLA)

1:1200
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mouse / IgG2a, kappa

Class

Monoclonal

Type

Antibody

Clone

2D11

Immunogen

HSPA1B (NP_005336, 531 a.a. approximately 611 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

See Label

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Sequence of this protein is as follows: VQRERVSAKN ALESYAFNMK SAVEDEGLKG KISEADKKKV LDKCQEVISW LDANTLAEKD EFEHKRKELE QVCNPIISGL Y

Target Information

This intronless gene encodes a 70 kDa heat shock protein which is a member of the heat shock protein 70 family. In conjunction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 68 kDa heat shock protein; Heat shock 70 kDa protein 1; heat shock 70 kDa protein 1/2; Heat shock 70 kDa protein 1A; heat shock 70 kDa protein 1A/1B; Heat shock 70 kDa protein 1B; Heat shock 70 kDa protein 2; heat shock 70kD protein 1B; heat shock 70kDa protein 1B; Heat shock protein; heat shock protein 70.1; Heat shock protein family A member 1A; Heat shock protein family A member 1B; heat shock protein, 70 kDa 1; HSP; HSP70-1; HSP70-1/HSP70-2; HSP70-1A; HSP70-2; HSP70.1; HSP70.1/HSP70.2; HSP70I

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Gene Aliases: Hcp70.1; hsp68; Hsp70; Hsp70-1; HSP70-1B; HSP70-2; Hsp70.1; HSP70.2; Hsp70a1; HSP72; HSPA1; HSPA1A; HSPA1B; Hspa2; HSX70

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UniProt ID: (Human) P0DMV8, (Mouse) P17879

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Entrez Gene ID: (Human) 3304, (Mouse) 15511, (Rat) 294254

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Function(s)
virus receptor activity G-protein coupled receptor binding receptor binding protein binding ATP binding ATPase activity enzyme binding heat shock protein binding ubiquitin protein ligase binding ATPase activity, coupled histone deacetylase binding protein binding involved in protein folding unfolded protein binding C3HC4-type RING finger domain binding molecular_function double-stranded RNA binding poly(A) RNA binding protein N-terminus binding
Process(es)
positive regulation of gene expression regulation of cell death regulation of protein ubiquitination negative regulation of protein ubiquitination positive regulation of interleukin-8 production cellular response to oxidative stress cellular response to heat protein refolding ATP metabolic process viral entry into host cell protein stabilization positive regulation of NF-kappaB transcription factor activity negative regulation of cell death cellular heat acclimation positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway negative regulation of inclusion body assembly regulation of cellular response to heat positive regulation of tumor necrosis factor-mediated signaling pathway negative regulation of extrinsic apoptotic signaling pathway in absence of ligand binding of sperm to zona pellucida response to heat negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process telomere maintenance response to ischemia DNA repair mRNA catabolic process response to unfolded protein negative regulation of cell proliferation response to radiation response to mechanical stimulus neuron differentiation negative regulation of cell growth response to ethanol positive regulation of erythrocyte differentiation positive regulation of neuron differentiation
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