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OriGene
HSPA8 Monoclonal Antibody (OTI1H3), TrueMAB™
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Product Details
CF505966
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG3
Class
Monoclonal
Type
Antibody
Clone
OTI1H3
Immunogen
Full length human recombinant protein of human HSPA8 produced in HEK293T cell.
Conjugate
Form
Lyophilized
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 8% trehalose
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)
Target Information
The HSP70 family is a set of highly conserved proteins that are induced by a variety of biological stresses, including heat stress, in every organism in which the proteins have been examined. The human HSP70 family members include: HSP70, a protein which is strongly inducible in all organisms but which is also constitutively expressed in primate cells; HSP72, a 72 kDa protein that is induced exclusively under stress conditions; HSC70, or cognate protein, is a 72 kDa, constitutively expressed, protein which is involved in the uncoating of clathrin coated vesicles; GRP78, or BiP, is a glucose regulated 78 kDa protein localized in the endoplasmic reticulum; and p75, or HSP75, a 75 kDa protein that is found within the mitochondria. HSC70 (also known as HSC71, HSC73, HSP73, p72, prp73) is expressed constitutively and is slightly heat-inducible. HSC70 binds to the exposed loop of clathrin light chains to promote uncoating and can also bind the cytoskeleton which may facilitate cytoskeletal rearrangements. HSC70 has been shown to stimulate lysosomal degradation of intracellular proteins and to retard both aggregation and folding of mitochondrial precursor proteins in vitro.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AAG2; constitutive heat shock protein 70; epididymis luminal protein 33; epididymis secretory sperm binding protein Li 72p; FAM10A1; Heat shock 70 kDa protein 8; heat shock 70kd protein 10; heat shock 70kDa protein 8; Heat shock cognate 71 kDa protein; heat shock cognate protein 54; Heat shock protein family A member 8; HIP; LAP; LAP-1; Lipopolysaccharide-associated protein 1; LPS-associated protein 1; MGC131511; MGC29929; N-myristoyltransferase inhibitor protein 71; Protein FAM10A1; SNC6
Gene Aliases: HEL-33; HEL-S-72p; HSC54; HSC70; HSC71; HSP71; HSP73; HSPA10; HSPA8; LAP-1; LAP1; NIP71
UniProt ID: (Human) P11142
Entrez Gene ID: (Human) 3312
G-protein coupled receptor binding
phosphatidylserine binding
protein binding
ATP binding
ATPase activity
enzyme binding
MHC class II protein complex binding
heat shock protein binding
ubiquitin protein ligase binding
ATPase activity, coupled
poly(A) RNA binding
unfolded protein binding
C3HC4-type RING finger domain binding
cadherin binding involved in cell-cell adhesion
mRNA splicing, via spliceosome
transcription, DNA-templated
protein folding
protein targeting to lysosome
response to unfolded protein
neurotransmitter secretion
cellular response to starvation
viral process
regulation of protein stability
protein refolding
regulation of protein complex assembly
regulation of mRNA stability
negative regulation of transcription, DNA-templated
ATP metabolic process
positive regulation of mRNA splicing, via spliceosome
chaperone mediated protein folding requiring cofactor
regulation of cell cycle
regulation of protein complex stability
chaperone-mediated autophagy
late endosomal microautophagy
protein targeting to lysosome involved in chaperone-mediated autophagy
chaperone-mediated protein transport involved in chaperone-mediated autophagy
clathrin coat disassembly
cell-cell adhesion
regulation of cellular response to heat
negative regulation of fibril organization
regulation of protein import
chaperone-mediated autophagy translocation complex disassembly
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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