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Invitrogen
HTR1B Polyclonal Antibody
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Product Details
PA5-33293
Product Specifications
Species Reactivity
Bat,
Bovine,
Dog,
Guinea pig,
Hamster,
Human,
Mouse,
Pig,
Rabbit,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic 16 amino acid peptide from 3rd cytoplasmic domain of human 5HT1B Receptor.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.1% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2550677
Target Information
Serotonin (5-hydroxytryptamine, 5-HT), originally discovered as a serum factor plays important roles in regulating diverse biological processes in central and peripheral nervous systems, cardiovascular systems, and gastrointestinal systems. Molecular cloning studies have identified 5 receptors belonging to the 5-HT1 subtypes. These receptors are negatively coupled to adenylyl cyclase. Radioligand binding studies suggest the presence of 5-HT1B (formerly known as 5-HT1DbR) sites in substantia nigra, dorsal subiculum, globus pallidus, and superior collicum. In situ hybridization studies show abundance of 5-HT1BR mRNA in CA1 pyramidal cells of hippocampus, Purkinje cells of cerebellum, olfactory tubercle, subthalamic nucleus and somewhat lower levels in the caudate-putamen, cortical areas, thalamic and hypothalamic nuclei.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 5-HT-1B; 5-HT-1D-beta; 5-HT1B; 5-HT1B receptor; 5-HT1B serotonin receptor; 5-HT1D beta; 5-HT1D beta receptor; 5-HT1D subtype beta; 5-HT<1B> receptor; 5-HTR1B; 5-hydroxytryptamine (serotonin ) receptor 1B; 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled; 5-hydroxytryptamine 1B receptor; 5-Hydroxytryptamine 1D receptor subtype beta; 5-hydroxytryptamine receptor 1B; 5HT1B Receptor; S12; serotonin (5-hydroxytryptamine (5HT)) receptor type 1B; Serotonin 1D beta receptor; Serotonin receptor 1B
Gene Aliases: 5-HT-1B; 5-HT-1D-beta; 5-HT1-LIKE; 5-HT1B; 5-HT1DB; 5ht1b; BOS_9492; HTR1B; HTR1D2; HTR1DB; S12
UniProt ID: (Human) P28222, (Rabbit) P49144, (Dog) P79250, (Mouse) P28334, (Rat) P28564, (Chinese hamster) P46636
Entrez Gene ID: (Human) 3351, (Bovine) 317707, (Pig) 397563, (Rabbit) 100009594, (Dog) 403741, (Mouse) 15551, (Rat) 25075, (Chinese hamster) 100689321
G-protein coupled receptor internalization
signal transduction
G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting serotonin receptor signaling pathway
protein kinase C-activating G-protein coupled receptor signaling pathway
serotonin receptor signaling pathway
chemical synaptic transmission
behavior
feeding behavior
response to toxic substance
regulation of dopamine secretion
negative regulation of serotonin secretion
negative regulation of cAMP biosynthetic process
negative regulation of synaptic transmission, GABAergic
cellular response to drug
response to cocaine
vasoconstriction
response to drug
drinking behavior
response to ethanol
bone remodeling
regulation of behavior
negative regulation of synaptic transmission, glutamatergic
cellular response to alkaloid
cellular response to temperature stimulus
response to mineralocorticoid
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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