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Invitrogen
HTR2A VHH-8His-Cys-tag Recombinant Alpaca Monoclonal Antibody (SAA1362)
Product Details
MA5-54599
Product Specifications
Species Reactivity
Human
Host/Isotype
Alpaca
/ VHH
Expression System
CHO cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
SAA1362
Immunogen
Recombinant Human HTR2A.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Metal-chelate chromatography
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
RRID
AB_3666849
Target Information
In platelets and gut, serotonin plays a major role in cardiovascular function and motility of the gastrointestinal tract, respectively. Serotonin mediates its effects through several of G protein coupled receptors, designated 5-HT receptors or alternatively SR receptors. The SR-2 receptors are comprised of three subtypes, SR-2A, SR-2B and SR-2C, which activate phospholipase C and release intracellular stores of calcium in response to serotonin. SR-2A has a specific role in tracheal smooth muscle contraction, bronchoconstriction and mediating aldosterone production, and it is also thought to play a role in several psychiatric disorders, including depression and schizophrenia. SR-2B is expressed in embryonic and adult cardiovascular tissues, gut and brain and plays an important role in the pathology of cardiac disorders. SR-2C is thought to mediate the effects of atypical antipsychotic drugs.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 5-HT-2; 5-HT2 receptor; 5-HT2A/2C; 5-HT2A/2C receptor; 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled; 5-hydroxytryptamine receptor 2A; 5HT2A Receptor; serotonin 5-HT-2A receptor; Serotonin receptor 2A; SR2A
Gene Aliases: 5-HT2A; HTR2; HTR2A
UniProt ID: (Human) P28223
Entrez Gene ID: (Human) 3356
temperature homeostasis
cellular calcium ion homeostasis
activation of phospholipase C activity
phospholipase C-activating serotonin receptor signaling pathway
serotonin receptor signaling pathway
chemical synaptic transmission
aging
memory
cell death
positive regulation of cell proliferation
positive regulation of phosphatidylinositol biosynthetic process
regulation of dopamine secretion
phosphatidylinositol 3-kinase signaling
artery smooth muscle contraction
urinary bladder smooth muscle contraction
sleep
response to drug
negative regulation of potassium ion transport
positive regulation of MAP kinase activity
protein localization to cytoskeleton
positive regulation of fat cell differentiation
positive regulation of glycolytic process
positive regulation of vasoconstriction
viral entry into host cell
regulation of hormone secretion
behavioral response to cocaine
positive regulation of peptidyl-tyrosine phosphorylation
regulation of behavior
detection of temperature stimulus involved in sensory perception of pain
detection of mechanical stimulus involved in sensory perception of pain
release of sequestered calcium ion into cytosol
negative regulation of synaptic transmission, glutamatergic
positive regulation of ERK1 and ERK2 cascade
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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