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Product Details
H00003357-D01P
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
HTR2B (NP_000858.2, 1 a.a. approximately 481 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MALSYRVSEL QSTIPEHILQ STFVHVISSN WSGLQTESIP EEMKQIVEEQ GNKLHWAALL ILMVIIPTIG GNTLVILAVS LEKKLQYATN YFLMSLAVAD LLVGLFVMPI ALLTIMFEAM WPLPLVLCPA WLFLDVLFST ASIMHLCAIS VDRYIAIKKP IQANQYNSRA TAFIKITVVW LISIGIAIPV PIKGIETDVD NPNNITCVLT KERFGDFMLF GSLAAFFTPL AIMIVTYFLT IHALQKKAYL VKNKPPQRLT WLTVSTVFQR DETPCSSPEK VAMLDGSRKD KALPNSGDET LMRRTSTIGK KSVQTISNEQ RASKVLGIVF FLFLLMWCPF FITNITLVLC DSCNQTTLQM LLEIFVWIGY VSSGVNPLVY TLFNKTFRDA FGRYITCNYR ATKSVKTLRK RSSKIYFRNP MAENSKFFKK HGIRNGINPA MYQSPMRLRS STIQSSSIIL LDTLLLTENE GDKTEERVSY V
Target Information
HTR2B is a g-protein coupled receptor for 5-hydroxytryptamine (serotonin). It functions as a receptor for various ergot alkaloid derivatives and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. HTR2B also plays a role in perception of pain, regulation of behavior. It is required to normal proliferation of embryonic cardiac myocytes and normal heart development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 5-HT 2B receptor; 5-HT-2B; 5-HT2b receptor; 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled; 5-hydroxytryptamine 2B receptor; 5-hydroxytryptamine receptor 2B; 5-hydroxytryptamine receptor 2B variant b; 5HT2B Receptor; Serotonin receptor 2B
Gene Aliases: 5-HT(2B); 5-HT-2B; 5-HT2B; HTR2B
UniProt ID: (Human) P41595
Entrez Gene ID: (Human) 3357
neural crest cell migration
positive regulation of cytokine production
positive regulation of endothelial cell proliferation
G-protein coupled receptor internalization
heart morphogenesis
cardiac muscle hypertrophy
cGMP biosynthetic process
cellular calcium ion homeostasis
G-protein coupled receptor signaling pathway
activation of phospholipase C activity
protein kinase C-activating G-protein coupled receptor signaling pathway
serotonin receptor signaling pathway
behavior
positive regulation of cell proliferation
negative regulation of autophagy
positive regulation of phosphatidylinositol biosynthetic process
neural crest cell differentiation
phosphatidylinositol 3-kinase signaling
intestine smooth muscle contraction
phosphorylation
calcium-mediated signaling
hepatic stellate cell activation
vasoconstriction
response to drug
negative regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of MAP kinase activity
positive regulation of GTPase activity
inositol phosphate metabolic process
embryonic morphogenesis
positive regulation of cytokine secretion
regulation of behavior
positive regulation of nitric-oxide synthase activity
release of sequestered calcium ion into cytosol
positive regulation of cell division
negative regulation of cell death
ERK1 and ERK2 cascade
positive regulation of ERK1 and ERK2 cascade
protein kinase C signaling
cellular response to amine stimulus
cellular response to temperature stimulus
cellular response to serotonin
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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