Invitrogen

HTR2B Polyclonal Antibody

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-33303

Applications
Tested Dilution
Publications

Immunohistochemistry (Paraffin) (IHC (P))

4-6 µg/mL
-
Product Specifications

Species Reactivity

Human, Non-human primate

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic 15 amino acid peptide from 2nd extracellular domain of human 5HT2B Receptor.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS

Contains

0.1% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2550687

Product Specific Information

This antibody is not recommended for use in ICC applications.

Percent identity with other species by BLAST analysis: Human, Chimpanzee, Gorilla, Orangutan, Gibbon, Monkey, Marmoset (100%) Bovine, Bat (93%).

Target Information

HTR2B is a g-protein coupled receptor for 5-hydroxytryptamine (serotonin). It functions as a receptor for various ergot alkaloid derivatives and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. HTR2B also plays a role in perception of pain, regulation of behavior. It is required to normal proliferation of embryonic cardiac myocytes and normal heart development.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 5-HT 2B receptor; 5-HT-2B; 5-HT2b receptor; 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled; 5-hydroxytryptamine 2B receptor; 5-hydroxytryptamine receptor 2B; 5-hydroxytryptamine receptor 2B variant b; 5HT2B Receptor; Serotonin receptor 2B

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Gene Aliases: 5-HT(2B); 5-HT-2B; 5-HT2B; HTR2B

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UniProt ID: (Human) P41595

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Entrez Gene ID: (Human) 3357

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Function(s)
G-protein alpha-subunit binding G-protein coupled serotonin receptor activity GTPase activator activity drug binding serotonin binding
Process(es)
neural crest cell migration positive regulation of cytokine production positive regulation of endothelial cell proliferation G-protein coupled receptor internalization heart morphogenesis cardiac muscle hypertrophy cGMP biosynthetic process cellular calcium ion homeostasis G-protein coupled receptor signaling pathway activation of phospholipase C activity protein kinase C-activating G-protein coupled receptor signaling pathway serotonin receptor signaling pathway behavior positive regulation of cell proliferation negative regulation of autophagy positive regulation of phosphatidylinositol biosynthetic process neural crest cell differentiation phosphatidylinositol 3-kinase signaling intestine smooth muscle contraction phosphorylation calcium-mediated signaling hepatic stellate cell activation vasoconstriction response to drug negative regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of MAP kinase activity positive regulation of GTPase activity inositol phosphate metabolic process embryonic morphogenesis positive regulation of cytokine secretion regulation of behavior positive regulation of nitric-oxide synthase activity release of sequestered calcium ion into cytosol positive regulation of cell division negative regulation of cell death ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade protein kinase C signaling cellular response to amine stimulus cellular response to temperature stimulus cellular response to serotonin
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