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Invitrogen
HTR7 Polyclonal Antibody
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Product Details
PA1-24575
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic 16 amino acid peptide from C-terminus of human 5HT7 Receptor.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.1% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_561318
Product Specific Information
PA1-24575 detects 5-HT7 Receptor in human samples.
Target Information
5-HT7 Receptor is a Serotonin Receptor with several functions, including regulation of the circadian rhythm and mediation of smooth-muscle relaxation in the vasculature and GI tract. This receptor has been implicated in depression, autism, and other neuropsychiatric disorders. Three protein isoforms have been documented: isoform a: 445aa; isoform b: 432aa; isoform d: 479aa. 5-HT7 Receptor has been reported in aorta, brain, heart, placenta, small intestine, spleen, artery, and vessel. An EST has been isolated from a testis library.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 5-HT-7; 5-HT-X; 5-HT7 receptor; 5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled); 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled; 5-hydroxytryptamine receptor 7; 5HT7 Receptor; HT7; OTTHUMP00000020077; OTTHUMP00000020078; OTTHUMP00000020079; Serotonin receptor 7
Gene Aliases: 5-HT7; HTR7
UniProt ID: (Human) P34969, (Mouse) P32304
Entrez Gene ID: (Human) 3363, (Mouse) 15566
smooth muscle contraction
signal transduction
G-protein coupled receptor signaling pathway
adenylate cyclase-activating serotonin receptor signaling pathway
serotonin receptor signaling pathway
chemical synaptic transmission
memory
circadian rhythm
positive regulation of neuron projection development
negative regulation of serotonin secretion
urinary bladder smooth muscle contraction
vasoconstriction
negative regulation of circadian sleep/wake cycle, REM sleep
behavioral response to pain
detection of mechanical stimulus involved in sensory perception of pain
response to corticosterone
micturition
long-term synaptic potentiation
dopaminergic neuron differentiation
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
blood circulation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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