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Invitrogen
HTR7 Recombinant Rabbit Monoclonal Antibody (4E6D2)
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Product Details
MA5-37958
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
4E6D2
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human 5HT7 Receptor (P34969)
Conjugate
Form
Liquid
Concentration
3 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2897878
Product Specific Information
Positive Samples: C6, SH-SY5Y, U-87MG, Mouse testis, Mouse brain, Mouse spleen, Rat testis, Rat brain
Immunogen sequence: MMDVNSSGRP DLYGHLRSFL LPEVGRGLPD LSPDGGADPV AGSWAPHLLS EVTASPAPTW DAPPDNASGC GEQINYGRVE KVVIGSILTL ITLLTIAGNC
Target Information
5-HT7 Receptor is a Serotonin Receptor with several functions, including regulation of the circadian rhythm and mediation of smooth-muscle relaxation in the vasculature and GI tract. This receptor has been implicated in depression, autism, and other neuropsychiatric disorders. Three protein isoforms have been documented: isoform a: 445aa; isoform b: 432aa; isoform d: 479aa. 5-HT7 Receptor has been reported in aorta, brain, heart, placenta, small intestine, spleen, artery, and vessel. An EST has been isolated from a testis library.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 5-HT-7; 5-HT-X; 5-HT7; 5-HT7 receptor; 5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled); 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled; 5-hydroxytryptamine receptor 7; 5HT7 Receptor; GPRFO; high affinity serotonin receptor (5HT7); HT7; OTTHUMP00000020077; OTTHUMP00000020078; OTTHUMP00000020079; Serotonin receptor 7
Gene Aliases: 5-HT7; 5Ht7; HTR7
UniProt ID: (Human) P34969, (Mouse) P32304, (Rat) P32305
Entrez Gene ID: (Human) 3363, (Mouse) 15566, (Rat) 65032
smooth muscle contraction
signal transduction
G-protein coupled receptor signaling pathway
adenylate cyclase-activating serotonin receptor signaling pathway
serotonin receptor signaling pathway
chemical synaptic transmission
memory
circadian rhythm
positive regulation of neuron projection development
negative regulation of serotonin secretion
urinary bladder smooth muscle contraction
vasoconstriction
negative regulation of circadian sleep/wake cycle, REM sleep
behavioral response to pain
detection of mechanical stimulus involved in sensory perception of pain
response to corticosterone
micturition
long-term synaptic potentiation
dopaminergic neuron differentiation
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
response to electrical stimulus
blood circulation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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