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Invitrogen
HUS1 Polyclonal Antibody
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Product Details
PA5-96312
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human HUS1 (NP_0044981)
Conjugate
Form
Liquid
Concentration
0.71 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2808114
Product Specific Information
Immunogen sequence: MKFRAKIVDG ACLNHFTRIS NMIAKLAKTC TLRISPDKLN FILCDKLANG GVSMWCELEQ ENFFNEFQME GVSAENNEIY LELTSENLSR ALKTAQNARA LKIKLTNKHF PCLTVSVELL SMSSSSRIVT HDIPIKVIPR KLWKDLQEPV VPDPDVSIYL PVLKTMKSVV EKMKNISNHL VIEANLDGEL NLKIETELVC VTTHFKDLGN PPLASESTHE DRNVEHMAEV HIDIRKLLQF LAGQQVNPTK ALCNIVNNKM VHFDLLHEDV SLQYFIPALS; Positive Samples: OVCAR-3, K-562, 293T; Cellular Location: Cytoplasm, Nucleus
Target Information
The protein encoded by this gene is a component of an evolutionarily conserved, genotoxin-activated checkpoint complex that is involved in the cell cycle arrest in response to DNA damage. This protein forms a heterotrimeric complex with checkpoint proteins RAD9 and RAD1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Checkpoint protein HUS1; hHUS1; HUS1 checkpoint homolog; HUS1 protein; hus1+-like protein; mHUS1
Gene Aliases: hHUS1; HUS1
UniProt ID: (Human) O60921, (Mouse) Q8BQY8
Entrez Gene ID: (Human) 3364, (Mouse) 15574
DNA damage checkpoint
double-strand break repair via homologous recombination
regulation of protein phosphorylation
DNA replication
DNA repair
nucleotide-excision repair
protein phosphorylation
cellular response to DNA damage stimulus
negative regulation of DNA replication
response to UV
embryo development
intra-S DNA damage checkpoint
mitotic DNA replication checkpoint
meiotic DNA integrity checkpoint
cellular response to ionizing radiation
regulation of signal transduction by p53 class mediator
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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