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Alomone Labs, LTD
HVCN1 Polyclonal Antibody
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FIGURE: 1 / 2
HVCN1 Antibody (AHC-001-200UL) in WB
Western blot analysis of mouse WEHI B-cell lymphoma (lanes 1 and 4), human HL-60 promyelocytic leukemia (lanes 2 and 5) and human THP-1 acute monocytic leukemia (lanes 3 and 6) cell lysates: - 1-3. Anti-HVCN1 Antibody (#AHC-001), (1:200).4-6. Anti-HVCN1 Antibody , preincubated with HVCN1 Blocking Peptide (#BLP-HC001).
Product Details
AHC-001-200UL
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
(C)GDDYHTWNVNYKK, corresponding to amino acid residues 32-44 of mouse HVCN1, Intracellular, N-terminus
Conjugate
Form
Lyophilized
Concentration
0.6 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 1% BSA
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C, protected from the light, for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 X g 5 min).
Target Information
HVCN1 (hydrogen voltage-gated channel 1), a voltage gated proton channel protein that is highly expressed in immune tissues, mediates the proton conductances required by phagocytic leukocytes for the oxidative burst that underlies microbial killing. HVCN1 moderates the voltage-dependent proton permeability of excitable membranes by allowing the flow of protons in accordance to their electrochemical gradient. HVCN1 is sensitive to zinc ions, and can be inhibited by them. HVCN1 may represent a new therapeutic target for B cell malignancies on continued signaling via the B cell antigen receptor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: HV1; Hydrogen voltage-gated channel 1; mVSOP; Voltage sensor domain-only protein; Voltage-gated hydrogen channel 1
Gene Aliases: 0610039P13Rik; AI450555; BTS; HV1; HVCN1; mVSOP; RGD1310788; UNQ578/PRO1140; VSOP; Vsop.
UniProt ID: (Human) Q96D96, (Mouse) Q3U2S8
Entrez Gene ID: (Human) 84329, (Mouse) 74096, (Rat) 304485
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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