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Invitrogen
HYAL1 Polyclonal Antibody
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Product Details
PA5-29816
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human HYAL1. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
0.99 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2547290
Product Specific Information
Recommended positive controls: HeLa, rat liver.
Predicted reactivity: Pig (81%), Bovine (80%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
This gene encodes a lysosomal hyaluronidase. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. This enzyme is active at an acidic pH and is the major hyaluronidase in plasma. Mutations in this gene are associated with mucopolysaccharidosis type IX, or hyaluronidase deficiency. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. Multiple transcript variants encoding different isoforms have been found for this gene.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Hyal-1; Hyaluronidase; hyaluronidase 1; Hyaluronidase-1; Hyaluronoglucosaminidase-1; LuCa-1; Lung carcinoma protein 1; plasma hyaluronidase; tumor suppressor LUCA-1
Gene Aliases: HYAL-1; HYAL1; LUCA1; MPS9; NAT6
UniProt ID: (Human) Q12794, (Rat) Q76HN1
Entrez Gene ID: (Human) 3373, (Rat) 367166
response to reactive oxygen species
carbohydrate metabolic process
inflammatory response
response to virus
positive regulation of epithelial cell migration
hyaluronan metabolic process
hyaluronan biosynthetic process
hyaluronan catabolic process
positive regulation of cell growth
negative regulation of cell growth
cellular response to platelet-derived growth factor stimulus
cellular response to fibroblast growth factor stimulus
positive regulation of angiogenesis
positive regulation of cell adhesion
positive regulation of growth
response to antibiotic
positive regulation of epithelial cell proliferation
cartilage development
embryonic skeletal joint morphogenesis
cellular response to interleukin-1
cellular response to tumor necrosis factor
cellular response to pH
cellular response to UV-B
positive regulation of hyaluranon cable assembly
chondroitin sulfate catabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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