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Invitrogen
HYAL1 Polyclonal Antibody
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HYAL1 Antibody (PA5-93104) in IHC (P)
Immunohistochemistry analysis of HYAL1 in paraffin-embedded human stomach. Samples were incubated with HYAL1 Polyclonal antibody (Product # PA5-93104) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
Product Details
PA5-93104
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 136-435 of human HYAL1 (NP_1493492)
Conjugate
Form
Liquid
Concentration
1.13 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2806626
Product Specific Information
Immunogen sequence: RWAFNWDTKD IYRQRSRALV QAQHPDWPAP QVEAVAQDQF QGAARAWMAG TLQLGRALRP RGLWGFYGFP DCYNYDFLSP NYTGQCPSGI RAQNDQLGWL WGQSRALYPS IYMPAVLEGT GKSQMYVQHR VAEAFRVAVA AGDPNLPVLP YVQIFYDTTN HFLPLDELEH SLGESAAQGA AGVVLWVSWE NTRTKESCQA IKEYMDTTLG PFILNVTSGA LLCSQALCSG HGRCVRRTSH PKALLLLNPA SFSIQLTPGG GPLSLRGALS LEDQAQMAVE FKCRCYPGWQ APWCERKSMW; Positive Samples: Mouse liver, Mouse lung; Cellular Location: Lysosome
Target Information
This gene encodes a lysosomal hyaluronidase. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. This enzyme is active at an acidic pH and is the major hyaluronidase in plasma. Mutations in this gene are associated with mucopolysaccharidosis type IX, or hyaluronidase deficiency. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Hyal-1; Hyaluronidase; hyaluronidase 1; Hyaluronidase-1; Hyaluronoglucosaminidase-1; LuCa-1; Lung carcinoma protein 1; plasma hyaluronidase; tumor suppressor LUCA-1
Gene Aliases: Hya1; HYAL-1; HYAL1; LUCA1; MPS9; NAT6
UniProt ID: (Human) Q12794, (Rat) Q76HN1, (Mouse) Q91ZJ9
Entrez Gene ID: (Human) 3373, (Rat) 367166, (Mouse) 15586
response to reactive oxygen species
carbohydrate metabolic process
inflammatory response
response to virus
positive regulation of epithelial cell migration
hyaluronan metabolic process
hyaluronan biosynthetic process
hyaluronan catabolic process
positive regulation of cell growth
negative regulation of cell growth
cellular response to platelet-derived growth factor stimulus
cellular response to fibroblast growth factor stimulus
positive regulation of angiogenesis
positive regulation of cell adhesion
positive regulation of growth
response to antibiotic
positive regulation of epithelial cell proliferation
cartilage development
embryonic skeletal joint morphogenesis
cellular response to interleukin-1
cellular response to tumor necrosis factor
cellular response to pH
cellular response to UV-B
positive regulation of hyaluranon cable assembly
metabolic process
chondroitin sulfate catabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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