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Invitrogen
Haptoglobin beta Polyclonal Antibody
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Product Details
PA5-142825
Product Specifications
Species Reactivity
Human,
Pig
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide with sequence C-STVPEKKTPKSP.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Ammonium sulfate precipitation
Storage buffer
TBS, pH 7.3, with 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2933468
Product Specific Information
Additional Information: This antibody is expected to recognize both reported isoforms (NP_005134.1; NP_001119574.1).
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:8,000.
Target Information
As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity, and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway. [PMID: 21248165]. The uncleaved form of allele alpha-2 (2-2), known as zonulin, plays a role in intestinal permeability, allowing intercellular tight junction disassembly, and controlling the equilibrium between tolerance and immunity to non-self antigens. [PMID: 21248165]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: binding peptide; Haptoglobin; haptoglobin alpha 1S; haptoglobin alpha(1S)-beta; haptoglobin alpha(2FS)-beta; haptoglobin, alpha polypeptide; haptoglobin, beta polypeptide; Zonulin
Gene Aliases: BP; HP; HP2ALPHA2; HPA1S
UniProt ID: (Human) P00738, (Pig) Q8SPS7
Entrez Gene ID: (Human) 3240, (Pig) 397061
immune system process
receptor-mediated endocytosis
defense response
acute-phase response
positive regulation of cell death
response to hydrogen peroxide
defense response to bacterium
negative regulation of oxidoreductase activity
cellular oxidant detoxification
negative regulation of hydrogen peroxide catabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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