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Proteintech
Hemoglobin alpha Polyclonal Antibody
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Product Details
14537-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Hemoglobin alpha Fusion Protein Ag6040 (1-142 aa encoded by BC050661)
Conjugate
Form
Liquid
Concentration
0.19 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody detects a major band around 14-16 kDa in the western blot analysis of heart tissue and K-562 cells. A higher band around 26-27 kDa can also be observed occasionally, which may represents the dimer form of HBA1. This antibody may cross-react with other hemoglobin chains.
Immunogen sequence: MVLSPADKT NVKAAWGKVG AHAGEYGAEA LERMFLSFPT TKTYFPHFDL SHGSAQVKGH GKKVADALTN AVAHVDDMPN ALSALSDLHA HKLRVDPVNF KLLSHCLLVT LAAHLPAEFT PAVHASLDKF LASVSTVLTS KYR (1-142 aa encoded by BC050661)
Target Information
The human alpha globin gene cluster located on chromosome 16 spans about 30 kb and includes seven loci: 5'- zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta - 3'. The alpha-2 (HBA2) and alpha-1 (HBA1) coding sequences are identical. These genes differ slightly over the 5' untranslated regions and the introns, but they differ significantly over the 3' untranslated regions. Two alpha chains plus two beta chains constitute HbA, which in normal adult life comprises about 97% of the total hemoglobin; alpha chains combine with delta chains to constitute HbA-2, which with HbF (fetal hemoglobin) makes up the remaining 3% of adult hemoglobin. Alpha thalassemias result from deletions of each of the alpha genes as well as deletions of both HBA2 and HBA1; some nondeletion alpha thalassemias have also been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: alpha 1 globin; alpha globin 1; alpha one globin; Alpha-1/2-globin; alpha-2 globin chain; Alpha-globin; delta globin; globin, alpha; haemaglobin alpha 1; hemoglobin alpha 1 chain; hemoglobin alpha 1 globin chain; Hemoglobin alpha chain; hemoglobin alpha, adult chain 1; hemoglobin alpha, adult chain 2; Hemoglobin alpha-1/2 chain; Hemoglobin subunit alpha; Hemoglobin subunit alpha-1/2; hemoglobin, alpha 1
Gene Aliases: GloA; Hba; Hba-a1; Hba-a2; HBA-T3; HBA1; HBA2; HBAM; Hbat1; HBH
UniProt ID: (Human) P69905, (Rat) P01946
Entrez Gene ID: (Human) 3039, (Mouse) 15122, (Rat) 25632, (Rat) 287167
in utero embryonic development
erythrocyte development
positive regulation of cell death
oxygen transport
response to hydrogen peroxide
hydrogen peroxide catabolic process
protein heterooligomerization
oxidation-reduction process
receptor-mediated endocytosis
bicarbonate transport
cellular oxidant detoxification
negative regulation of blood pressure
regulation of sensory perception of pain
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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