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Hemoglobin epsilon Polyclonal Antibody

Hemoglobin epsilon Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Hemoglobin epsilon Antibody (12361-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human placenta using 12361-1-AP (Hemoglobin epsilon antibody) at dilution of 1:50 (under 40x lens).

Hemoglobin epsilon Antibody in Western Blot (WB)

Hemoglobin epsilon Antibody in Flow Cytometry (Flow)

Product Image Gallery

Product Details

12361-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 5 publications 5 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Flow Cytometry (Flow)

0.2 µg/1x10^6 cells

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Hemoglobin epsilon Fusion Protein Ag3026 (1-147 aa encoded by BC015537)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.39 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody can be used to label and isolate fetal cells from maternal blood and may be useful in prenatal diagnosis.

Immunogen sequence: MVHFTAEEK AAVTSLWSKM NVEEAGGEAL GRLLVVYPWT QRFFDSFGNL SSPSAILGNP KVKAHGKKVL TSFGDAIKNM DNLKPAFAKL SELHCDKLHV DPENFKLLGN VMVIILATHF GKEFTPEVQA AWQKLVSAVA IALAHKYH (1-147 aa encoded by BC015537)

Target Information

The epsilon globin gene (HBE) is normally expressed in the embryonic yolk sac: two epsilon chains together with two zeta chains (an alpha-like globin) constitute the embryonic hemoglobin Hb Gower I; two epsilon chains together with two alpha chains form the embryonic Hb Gower II. Both of these embryonic hemoglobins are normally supplanted by fetal, and later, adult hemoglobin. The five beta-like globin genes are found within a 45 kb cluster on chromosome 11 in the following order: 5'-epsilon - G-gamma - A-gamma - delta - beta-3'.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Requirement for antiapoptotic MCL-1 during early erythropoiesis.

Blood

Turnis ME,Kaminska E,Smith KH,Kartchner BJ,Vogel P,Laxton JD,Ashmun RA,Ney PA,Opferman JT

Thu Apr 08 00:00:00 UTC 2021

Long noncoding RNA CCDC26 as a modulator of transcriptional switching between fetal and embryonic globins.

Biochimica et biophysica acta. Molecular cell research

Hirano T,Tsuruda T,Tanaka Y,Harada H,Yamazaki T,Ishida A

Mon Mar 01 00:00:00 UTC 2021

Transcriptional fine-tuning of microRNA-223 levels directs lineage choice of human hematopoietic progenitors.

Cell death and differentiation

Vian L,Di Carlo M,Pelosi E,Fazi F,Santoro S,Cerio AM,Boe A,Rotilio V,Billi M,Racanicchi S,Testa U,Grignani F,Nervi C

Sat Feb 01 00:00:00 UTC 2014

Transcriptional fine-tuning of microRNA-223 levels directs lineage choice of human hematopoietic progenitors.

Cell death and differentiation

Vian L,Di Carlo M,Pelosi E,Fazi F,Santoro S,Cerio AM,Boe A,Rotilio V,Billi M,Racanicchi S,Testa U,Grignani F,Nervi C

Sat Feb 01 00:00:00 UTC 2014

A feedback loop consisting of microRNA 23a/27a and the β-like globin suppressors KLF3 and SP1 regulates globin gene expression.

Molecular and cellular biology

Ma Y,Wang B,Jiang F,Wang D,Liu H,Yan Y,Dong H,Wang F,Gong B,Zhu Y,Dong L,Yin H,Zhang Z,Zhao H,Wu Z,Zhang J,Zhou J,Yu J

Tue Oct 01 00:00:00 UTC 2013

A feedback loop consisting of microRNA 23a/27a and the β-like globin suppressors KLF3 and SP1 regulates globin gene expression.

Molecular and cellular biology

Ma Y,Wang B,Jiang F,Wang D,Liu H,Yan Y,Dong H,Wang F,Gong B,Zhu Y,Dong L,Yin H,Zhang Z,Zhao H,Wu Z,Zhang J,Zhou J,Yu J

Tue Oct 01 00:00:00 UTC 2013

A comparison of E15.5 fetus and newborn rat serum proteomes.

Proteome science

Wei L,Jia L,Zhu L,Ma S,Zhang D,Shao C,Sun W,Gao Y

Wed Nov 07 00:00:00 UTC 2012

A comparison of E15.5 fetus and newborn rat serum proteomes.

Proteome science

Wei L,Jia L,Zhu L,Ma S,Zhang D,Shao C,Sun W,Gao Y

Wed Nov 07 00:00:00 UTC 2012

NFI-A directs the fate of hematopoietic progenitors to the erythroid or granulocytic lineage and controls beta-globin and G-CSF receptor expression.

Blood

Starnes LM,Sorrentino A,Pelosi E,Ballarino M,Morsilli O,Biffoni M,Santoro S,Felli N,Castelli G,De Marchis ML,Mastroberardino G,Gabbianelli M,Fatica A,Bozzoni I,Nervi C,Peschle C

Thu Aug 27 00:00:00 UTC 2009

NFI-A directs the fate of hematopoietic progenitors to the erythroid or granulocytic lineage and controls beta-globin and G-CSF receptor expression.

Blood

Starnes LM,Sorrentino A,Pelosi E,Ballarino M,Morsilli O,Biffoni M,Santoro S,Felli N,Castelli G,De Marchis ML,Mastroberardino G,Gabbianelli M,Fatica A,Bozzoni I,Nervi C,Peschle C

Thu Aug 27 00:00:00 UTC 2009

Bioinformatics

Protein Aliases: epsilon 1 globin; epsilon globin; Epsilon-globin; Hemoglobin epsilon chain; Hemoglobin subunit epsilon; hemoglobin, epsilon 1

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Gene Aliases: HBE; HBE1

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UniProt ID: (Human) P02100

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Entrez Gene ID: (Human) 3046, (Rat) 293267

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Function(s)

oxygen transporter activity iron ion binding oxygen binding heme binding hemoglobin alpha binding

Process(es)

blood coagulation oxygen transport protein heterooligomerization negative regulation of transcription from RNA polymerase II promoter

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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Hemoglobin epsilon Polyclonal Antibody

Hemoglobin epsilon Antibody (12361-1-AP) in IHC (P)

Product Details

12361-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Flow Cytometry (Flow)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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